node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEP62310.1 | SEP65384.1 | SAMN04488097_0115 | SAMN04488097_0219 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | 0.481 |
SEP62310.1 | SEP68515.1 | SAMN04488097_0115 | SAMN04488097_0314 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Acyl-CoA hydrolase. | 0.748 |
SEP62310.1 | SEP80949.1 | SAMN04488097_0115 | SAMN04488097_0716 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.938 |
SEP62310.1 | SEQ23513.1 | SAMN04488097_0115 | SAMN04488097_1768 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Heterodimeric methylmalonyl-CoA mutase large subunit precursor. | 0.792 |
SEP62310.1 | SEQ32135.1 | SAMN04488097_0115 | SAMN04488097_2033 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | 0.777 |
SEP62310.1 | SEQ85497.1 | SAMN04488097_0115 | SAMN04488097_3242 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 3-hydroxyacyl-CoA dehydrogenase. | 0.810 |
SEP62310.1 | icmF | SAMN04488097_0115 | SAMN04488097_1286 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.821 |
SEP62310.1 | sdhA | SAMN04488097_0115 | SAMN04488097_0220 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Succinate dehydrogenase subunit A. | 0.490 |
SEP62310.1 | sucC | SAMN04488097_0115 | SAMN04488097_1170 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.934 |
SEP62310.1 | sucD | SAMN04488097_0115 | SAMN04488097_2205 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.926 |
SEP65384.1 | SEP62310.1 | SAMN04488097_0219 | SAMN04488097_0115 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.481 |
SEP65384.1 | SEP68515.1 | SAMN04488097_0219 | SAMN04488097_0314 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | Acyl-CoA hydrolase. | 0.754 |
SEP65384.1 | SEP80949.1 | SAMN04488097_0219 | SAMN04488097_0716 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.602 |
SEP65384.1 | SEQ23513.1 | SAMN04488097_0219 | SAMN04488097_1768 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | Heterodimeric methylmalonyl-CoA mutase large subunit precursor. | 0.723 |
SEP65384.1 | SEQ32135.1 | SAMN04488097_0219 | SAMN04488097_2033 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. | 0.532 |
SEP65384.1 | icmF | SAMN04488097_0219 | SAMN04488097_1286 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.725 |
SEP65384.1 | sdhA | SAMN04488097_0219 | SAMN04488097_0220 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | Succinate dehydrogenase subunit A. | 0.999 |
SEP65384.1 | sucC | SAMN04488097_0219 | SAMN04488097_1170 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.990 |
SEP65384.1 | sucD | SAMN04488097_0219 | SAMN04488097_2205 | Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.992 |
SEP68515.1 | SEP62310.1 | SAMN04488097_0314 | SAMN04488097_0115 | Acyl-CoA hydrolase. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.748 |