node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEQ49342.1 | SEQ49422.1 | SAMN04488097_2240 | SAMN04488097_2243 | Molybdate transport system ATP-binding protein. | Acetolactate synthase, small subunit. | 0.467 |
SEQ49342.1 | ilvA | SAMN04488097_2240 | SAMN04488097_2239 | Molybdate transport system ATP-binding protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.803 |
SEQ49342.1 | ilvC | SAMN04488097_2240 | SAMN04488097_2242 | Molybdate transport system ATP-binding protein. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.777 |
SEQ49422.1 | SEQ49342.1 | SAMN04488097_2243 | SAMN04488097_2240 | Acetolactate synthase, small subunit. | Molybdate transport system ATP-binding protein. | 0.467 |
SEQ49422.1 | SEQ49447.1 | SAMN04488097_2243 | SAMN04488097_2244 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SEQ49422.1 | SEQ59633.1 | SAMN04488097_2243 | SAMN04488097_2612 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase. | 0.917 |
SEQ49422.1 | SEQ86389.1 | SAMN04488097_2243 | SAMN04488097_3282 | Acetolactate synthase, small subunit. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.995 |
SEQ49422.1 | ilvA | SAMN04488097_2243 | SAMN04488097_2239 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.994 |
SEQ49422.1 | ilvC | SAMN04488097_2243 | SAMN04488097_2242 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
SEQ49422.1 | ilvD | SAMN04488097_2243 | SAMN04488097_2246 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.960 |
SEQ49422.1 | leuB | SAMN04488097_2243 | SAMN04488097_2609 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.991 |
SEQ49422.1 | leuC | SAMN04488097_2243 | SAMN04488097_2611 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.836 |
SEQ49422.1 | leuD | SAMN04488097_2243 | SAMN04488097_2610 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.877 |
SEQ49447.1 | SEQ49422.1 | SAMN04488097_2244 | SAMN04488097_2243 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SEQ49447.1 | SEQ59633.1 | SAMN04488097_2244 | SAMN04488097_2612 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase. | 0.853 |
SEQ49447.1 | SEQ86389.1 | SAMN04488097_2244 | SAMN04488097_3282 | Acetolactate synthase, large subunit. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.922 |
SEQ49447.1 | ilvA | SAMN04488097_2244 | SAMN04488097_2239 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.988 |
SEQ49447.1 | ilvC | SAMN04488097_2244 | SAMN04488097_2242 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
SEQ49447.1 | ilvD | SAMN04488097_2244 | SAMN04488097_2246 | Acetolactate synthase, large subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.989 |
SEQ49447.1 | leuB | SAMN04488097_2244 | SAMN04488097_2609 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.985 |