BTMF_LOCUS6467 protein (Brugia timori) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BTMF_LOCUS6467

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)

Predicted Functional Partners:

BTMF_LOCUS854

0.947

A0A0R3QWC2

0.947

BTMF_LOCUS2624

0.932

BTMF_LOCUS7951

0.929

BTMF_LOCUS3650

0.920

A0A0R3QHJ3

0.920

BTMF_LOCUS9741

0.920

BTMF_LOCUS495

0.915

BTMF_LOCUS253

0.901

A0A158PT29

0.899

Your Current Organism:

Brugia timori

NCBI taxonomy Id: 42155
Other names: B. timori

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3QHJ3	BTMF_LOCUS253	A0A0R3QHJ3	A0A0R3Q3L9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.531
A0A0R3QHJ3	BTMF_LOCUS495	A0A0R3QHJ3	A0A0R3Q4B3	Uncharacterized protein.	Small ubiquitin-related modifier.	0.531
A0A0R3QHJ3	BTMF_LOCUS6467	A0A0R3QHJ3	A0A0R3QL60	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.920
A0A0R3QWC2	A0A158PT29	A0A0R3QWC2	A0A158PT29	HRDC domain-containing protein.	Uncharacterized protein.	0.839
A0A0R3QWC2	BTMF_LOCUS253	A0A0R3QWC2	A0A0R3Q3L9	HRDC domain-containing protein.	Ubiquitin-like domain-containing protein.	0.878
A0A0R3QWC2	BTMF_LOCUS2624	A0A0R3QWC2	A0A0R3QAE1	HRDC domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.864
A0A0R3QWC2	BTMF_LOCUS495	A0A0R3QWC2	A0A0R3Q4B3	HRDC domain-containing protein.	Small ubiquitin-related modifier.	0.878
A0A0R3QWC2	BTMF_LOCUS6467	A0A0R3QWC2	A0A0R3QL60	HRDC domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.947
A0A0R3QWC2	BTMF_LOCUS854	A0A0R3QWC2	A0A0R3Q5C2	HRDC domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.681
A0A158PT29	A0A0R3QWC2	A0A158PT29	A0A0R3QWC2	Uncharacterized protein.	HRDC domain-containing protein.	0.839
A0A158PT29	BTMF_LOCUS253	A0A158PT29	A0A0R3Q3L9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.985
A0A158PT29	BTMF_LOCUS495	A0A158PT29	A0A0R3Q4B3	Uncharacterized protein.	Small ubiquitin-related modifier.	0.985
A0A158PT29	BTMF_LOCUS6467	A0A158PT29	A0A0R3QL60	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.899
A0A158PT29	BTMF_LOCUS854	A0A158PT29	A0A0R3Q5C2	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.839
BTMF_LOCUS253	A0A0R3QHJ3	A0A0R3Q3L9	A0A0R3QHJ3	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.531
BTMF_LOCUS253	A0A0R3QWC2	A0A0R3Q3L9	A0A0R3QWC2	Ubiquitin-like domain-containing protein.	HRDC domain-containing protein.	0.878
BTMF_LOCUS253	A0A158PT29	A0A0R3Q3L9	A0A158PT29	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.985
BTMF_LOCUS253	BTMF_LOCUS2624	A0A0R3Q3L9	A0A0R3QAE1	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.986
BTMF_LOCUS253	BTMF_LOCUS3650	A0A0R3Q3L9	A0A0R3QDB5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.531
BTMF_LOCUS253	BTMF_LOCUS6467	A0A0R3Q3L9	A0A0R3QL60	Ubiquitin-like domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.901

page 1 of 3

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About