BTMF_LOCUS6467 protein (Brugia timori) - STRING interaction network

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BTMF_LOCUS6467

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)

Predicted Functional Partners:

BTMF_LOCUS2624

0.974

BTMF_LOCUS1334

0.967

A0A0R3R071

0.963

BTMF_LOCUS6018

0.959

A0A158PT29

0.956

BTMF_LOCUS495

0.953

A0A0R3R0G9

0.942

A0A0R3RD06

0.935

BTMF_LOCUS854

0.932

A0A0R3QWC2

0.932

Your Current Organism:

Brugia timori

NCBI taxonomy Id: 42155
Other names: B. timori

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3QWC2	A0A0R3R071	A0A0R3QWC2	A0A0R3R071	HRDC domain-containing protein.	PCNA_C domain-containing protein.	0.963
A0A0R3QWC2	A0A0R3R0G9	A0A0R3QWC2	A0A0R3R0G9	HRDC domain-containing protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.975
A0A0R3QWC2	A0A0R3RD06	A0A0R3QWC2	A0A0R3RD06	HRDC domain-containing protein.	SP-RING-type domain-containing protein.	0.927
A0A0R3QWC2	A0A158PT29	A0A0R3QWC2	A0A158PT29	HRDC domain-containing protein.	Uncharacterized protein.	0.926
A0A0R3QWC2	BTMF_LOCUS1334	A0A0R3QWC2	A0A0R3Q6Q2	HRDC domain-containing protein.	ERCC4 domain-containing protein.	0.978
A0A0R3QWC2	BTMF_LOCUS2624	A0A0R3QWC2	A0A0R3QAE1	HRDC domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.950
A0A0R3QWC2	BTMF_LOCUS495	A0A0R3QWC2	A0A0R3Q4B3	HRDC domain-containing protein.	Small ubiquitin-related modifier.	0.930
A0A0R3QWC2	BTMF_LOCUS6018	A0A0R3QWC2	A0A0R3QK16	HRDC domain-containing protein.	Uncharacterized protein.	0.966
A0A0R3QWC2	BTMF_LOCUS6467	A0A0R3QWC2	A0A0R3QL60	HRDC domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.932
A0A0R3QWC2	BTMF_LOCUS854	A0A0R3QWC2	A0A0R3Q5C2	HRDC domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.681
A0A0R3R071	A0A0R3QWC2	A0A0R3R071	A0A0R3QWC2	PCNA_C domain-containing protein.	HRDC domain-containing protein.	0.963
A0A0R3R071	A0A0R3R0G9	A0A0R3R071	A0A0R3R0G9	PCNA_C domain-containing protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.915
A0A0R3R071	A0A0R3RD06	A0A0R3R071	A0A0R3RD06	PCNA_C domain-containing protein.	SP-RING-type domain-containing protein.	0.698
A0A0R3R071	A0A158PT29	A0A0R3R071	A0A158PT29	PCNA_C domain-containing protein.	Uncharacterized protein.	0.974
A0A0R3R071	BTMF_LOCUS1334	A0A0R3R071	A0A0R3Q6Q2	PCNA_C domain-containing protein.	ERCC4 domain-containing protein.	0.970
A0A0R3R071	BTMF_LOCUS2624	A0A0R3R071	A0A0R3QAE1	PCNA_C domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.991
A0A0R3R071	BTMF_LOCUS495	A0A0R3R071	A0A0R3Q4B3	PCNA_C domain-containing protein.	Small ubiquitin-related modifier.	0.987
A0A0R3R071	BTMF_LOCUS6018	A0A0R3R071	A0A0R3QK16	PCNA_C domain-containing protein.	Uncharacterized protein.	0.848
A0A0R3R071	BTMF_LOCUS6467	A0A0R3R071	A0A0R3QL60	PCNA_C domain-containing protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.963
A0A0R3R071	BTMF_LOCUS854	A0A0R3R071	A0A0R3Q5C2	PCNA_C domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.963

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