| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IQ63_18975 | IQ63_18985 | IQ63_18975 | IQ63_18985 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| IQ63_18975 | gcvP | IQ63_18975 | IQ63_13885 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.895 |
| IQ63_18975 | gcvT_2 | IQ63_18975 | IQ63_02740 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.971 |
| IQ63_18975 | glyA2_1 | IQ63_18975 | IQ63_18965 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
| IQ63_18975 | glyA2_2 | IQ63_18975 | IQ63_02730 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.713 |
| IQ63_18975 | glyA_2 | IQ63_18975 | IQ63_14780 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.713 |
| IQ63_18975 | mlr_2 | IQ63_18975 | IQ63_42150 | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
| IQ63_18985 | IQ63_18975 | IQ63_18985 | IQ63_18975 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| IQ63_18985 | gcvP | IQ63_18985 | IQ63_13885 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.904 |
| IQ63_18985 | gcvT_2 | IQ63_18985 | IQ63_02740 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.960 |
| IQ63_18985 | glyA2_1 | IQ63_18985 | IQ63_18965 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
| IQ63_18985 | glyA2_2 | IQ63_18985 | IQ63_02730 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.751 |
| IQ63_18985 | glyA_2 | IQ63_18985 | IQ63_14780 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.751 |
| IQ63_18985 | mlr_2 | IQ63_18985 | IQ63_42150 | Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.986 |
| gcvH | gcvP | IQ63_02735 | IQ63_13885 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT_2 | IQ63_02735 | IQ63_02740 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvH | glyA2_1 | IQ63_02735 | IQ63_18965 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
| gcvH | glyA2_2 | IQ63_02735 | IQ63_02730 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
| gcvH | glyA_2 | IQ63_02735 | IQ63_14780 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.945 |
| gcvH | metH | IQ63_02735 | IQ63_35025 | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.761 |