STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A2T6ZM74Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (556 aa)    
Predicted Functional Partners:
A0A2T6ZCD5
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
   
 0.975
A0A2T6ZIZ6
Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
   
 0.966
A0A2T6ZIY9
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.954
A0A2T7A4X7
Uncharacterized protein.
    
 0.947
A0A2T6ZLQ4
Uncharacterized protein.
    
 0.931
A0A2T6ZPA0
SET domain-containing protein.
     
 0.931
A0A2T6ZZU0
Uncharacterized protein.
    
 0.929
A0A2T6ZML8
Beta centromeric histone H3.
   
 0.927
A0A2T6ZRR1
Histone-fold-containing protein.
   
 0.927
A0A2T6ZWU2
Histone-fold-containing protein.
   
 0.927
Your Current Organism:
Tuber borchii
NCBI taxonomy Id: 42251
Other names: T. borchii, whitish truffle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.