node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALA56488.1 | aclA | NITMOv2_0044 | NITMOv2_0691 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.463 |
ALA56488.1 | acsA | NITMOv2_0044 | NITMOv2_3181 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.792 |
ALA56488.1 | atoB | NITMOv2_0044 | NITMOv2_0057 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.509 |
ALA56488.1 | prpB | NITMOv2_0044 | NITMOv2_0046 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.850 |
ALA56488.1 | prpC | NITMOv2_0044 | NITMOv2_0045 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.856 |
ALA56488.1 | prpD | NITMOv2_0044 | NITMOv2_0047 | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 2-methylcitrate dehydratase. | 0.798 |
accC | aclA | NITMOv2_2072 | NITMOv2_0691 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.902 |
accC | acsA | NITMOv2_2072 | NITMOv2_3181 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.933 |
accC | atoB | NITMOv2_2072 | NITMOv2_0057 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.944 |
accC | leuA | NITMOv2_2072 | NITMOv2_0858 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.975 |
accC | prpB | NITMOv2_2072 | NITMOv2_0046 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.831 |
accC | sucC | NITMOv2_2072 | NITMOv2_0696 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.836 |
accC | sucD | NITMOv2_2072 | NITMOv2_0697 | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.828 |
aclA | ALA56488.1 | NITMOv2_0691 | NITMOv2_0044 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.463 |
aclA | accC | NITMOv2_0691 | NITMOv2_2072 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.902 |
aclA | acsA | NITMOv2_0691 | NITMOv2_3181 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.868 |
aclA | atoB | NITMOv2_0691 | NITMOv2_0057 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. | 0.941 |
aclA | prpB | NITMOv2_0691 | NITMOv2_0046 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. | 0.860 |
aclA | prpC | NITMOv2_0691 | NITMOv2_0045 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. | 0.611 |
aclA | prpD | NITMOv2_0691 | NITMOv2_0047 | ATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-methylcitrate dehydratase. | 0.837 |