node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
glyA | pucG | NITMOv2_0125 | NITMOv2_1039 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Purine catabolism protein PucG. | 0.922 |
glyA | trpA | NITMOv2_0125 | NITMOv2_2290 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.928 |
glyA | trpB | NITMOv2_0125 | NITMOv2_2291 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.923 |
pabA | pabB | NITMOv2_2296 | NITMOv2_4183 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Para-aminobenzoate synthase component 1. | 0.999 |
pabA | trpA | NITMOv2_2296 | NITMOv2_2290 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.984 |
pabA | trpB | NITMOv2_2296 | NITMOv2_2291 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.978 |
pabA | trpC | NITMOv2_2296 | NITMOv2_2294 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
pabA | trpD | NITMOv2_2296 | NITMOv2_0336 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.993 |
pabA | trpD-2 | NITMOv2_2296 | NITMOv2_2295 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
pabA | trpE | NITMOv2_2296 | NITMOv2_2297 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
pabA | trpF | NITMOv2_2296 | NITMOv2_2292 | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.999 |
pabB | pabA | NITMOv2_4183 | NITMOv2_2296 | Para-aminobenzoate synthase component 1. | Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
pabB | trpA | NITMOv2_4183 | NITMOv2_2290 | Para-aminobenzoate synthase component 1. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.948 |
pabB | trpB | NITMOv2_4183 | NITMOv2_2291 | Para-aminobenzoate synthase component 1. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.934 |
pabB | trpC | NITMOv2_4183 | NITMOv2_2294 | Para-aminobenzoate synthase component 1. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.994 |
pabB | trpD | NITMOv2_4183 | NITMOv2_0336 | Para-aminobenzoate synthase component 1. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.990 |
pabB | trpD-2 | NITMOv2_4183 | NITMOv2_2295 | Para-aminobenzoate synthase component 1. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.990 |
pabB | trpE | NITMOv2_4183 | NITMOv2_2297 | Para-aminobenzoate synthase component 1. | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.825 |
pabB | trpF | NITMOv2_4183 | NITMOv2_2292 | Para-aminobenzoate synthase component 1. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.952 |
pucG | glyA | NITMOv2_1039 | NITMOv2_0125 | Purine catabolism protein PucG. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |