STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribE-2Riboflavin synthase. (217 aa)    
Predicted Functional Partners:
ribBA
Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 0.999
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
 0.999
ribE
Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.998
ribF
Riboflavin biosynthesis protein RibF; Belongs to the ribF family.
  
 
 0.932
hisI
Fused Phosphoribosyl-AMP cyclohydrolase and Phosphoribosyl-ATP diphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the N-terminal section; belongs to the PRA-CH family.
  
    0.796
rpmE
50S ribosomal subunit protein L31; Binds the 23S rRNA.
   
    0.746
ALA59588.1
Homologs of previously reported genes of unknown function.
       0.606
ALA59587.1
Homologs of previously reported genes of unknown function.
       0.597
ALA59586.1
Putative Multidrug resistance protein MdtG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
    0.596
ALA58034.1
Putative Histidinol-phosphate transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.497
Your Current Organism:
Nitrospira moscoviensis
NCBI taxonomy Id: 42253
Other names: DSM 10035, N. moscoviensis, Nitrospira moscoviensis Ehrich et al. 2001, strain NSP M-1
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