Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CASC4Cancer susceptibility 4. (405 aa)    
Predicted Functional Partners:
TM9SF3
Transmembrane 9 superfamily member 3.
   
  
 0.894
CCDC186
Coiled-coil domain containing 186.
      
 0.879
GRAMD2B
GRAM domain containing 2B.
    
   0.788
TMEM87A
Transmembrane protein 87A.
      
 0.760
VTI1A
Vesicle transport through interaction with t-SNAREs 1A.
     
 0.751
VTI1B
Vesicle transport through interaction with t-SNAREs 1B.
     
 0.716
CASC3
CASC3 exon junction complex subunit.
     
 0.675
ARFIP1
ADP ribosylation factor interacting protein 1.
   
  
 0.635
TBC1D25
TBC1 domain family member 25.
    
 
 0.625
SPRYD3
SPRY domain containing 3.
      
 0.622
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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