Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CHEK2Checkpoint kinase 2. (553 aa)    
Predicted Functional Partners:
TP53
Tumor protein p53.
    
 0.998
ATM
ATM serine/threonine kinase.
    
 0.996
BRCA1
BRCA1 DNA repair associated.
   
 0.992
MDM2
MDM2 proto-oncogene.
    
 0.992
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.981
ATR
ATR serine/threonine kinase.
    
 
 0.975
ENSSARP00000011203
annotation not available
   
 0.971
CDC25A
Cell division cycle 25A.
   
 0.970
CDC25C
Cell division cycle 25C.
   
 0.970
PRKDC
Protein kinase, DNA-activated, catalytic subunit.
    
 
 0.965
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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