ITM2B protein (Sorex araneus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

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Co-occurrence

Co-expression

Experiments

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[Homology]

Score

ITM2B

Integral membrane protein 2B. (266 aa)

Predicted Functional Partners:

ENSSARP00000004844

0.941

ENSSARP00000001368

0.818

ENSSARP00000004404

0.797

APLP2

0.772

TMEM59

0.749

ENSSARP00000001271

0.695

HNRNPD

0.678

JUP

0.659

ENSSARP00000005121

0.654

FNDC3A

0.648

Your Current Organism:

Sorex araneus

NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP2	ENSSARP00000001368	ENSSARP00000006569	ENSSARP00000001368	Amyloid beta precursor like protein 2.	annotation not available	0.975
APLP2	ENSSARP00000004844	ENSSARP00000006569	ENSSARP00000004844	Amyloid beta precursor like protein 2.	annotation not available	0.993
APLP2	ITM2B	ENSSARP00000006569	ENSSARP00000001345	Amyloid beta precursor like protein 2.	Integral membrane protein 2B.	0.772
ENSSARP00000001271	ITM2B	ENSSARP00000001271	ENSSARP00000001345	annotation not available	Integral membrane protein 2B.	0.695
ENSSARP00000001368	APLP2	ENSSARP00000001368	ENSSARP00000006569	annotation not available	Amyloid beta precursor like protein 2.	0.975
ENSSARP00000001368	ITM2B	ENSSARP00000001368	ENSSARP00000001345	annotation not available	Integral membrane protein 2B.	0.818
ENSSARP00000004404	ITM2B	ENSSARP00000004404	ENSSARP00000001345	annotation not available	Integral membrane protein 2B.	0.797
ENSSARP00000004404	JUP	ENSSARP00000004404	ENSSARP00000005742	annotation not available	Junction plakoglobin.	0.448
ENSSARP00000004844	APLP2	ENSSARP00000004844	ENSSARP00000006569	annotation not available	Amyloid beta precursor like protein 2.	0.993
ENSSARP00000004844	ITM2B	ENSSARP00000004844	ENSSARP00000001345	annotation not available	Integral membrane protein 2B.	0.941
ENSSARP00000005121	ITM2B	ENSSARP00000005121	ENSSARP00000001345	annotation not available	Integral membrane protein 2B.	0.654
FNDC3A	ITM2B	ENSSARP00000003627	ENSSARP00000001345	Fibronectin type III domain containing 3A.	Integral membrane protein 2B.	0.648
HNRNPD	ITM2B	ENSSARP00000006237	ENSSARP00000001345	Heterogeneous nuclear ribonucleoprotein D.	Integral membrane protein 2B.	0.678
HNRNPD	TMEM59	ENSSARP00000006237	ENSSARP00000003300	Heterogeneous nuclear ribonucleoprotein D.	Transmembrane protein 59.	0.575
ITM2B	APLP2	ENSSARP00000001345	ENSSARP00000006569	Integral membrane protein 2B.	Amyloid beta precursor like protein 2.	0.772
ITM2B	ENSSARP00000001271	ENSSARP00000001345	ENSSARP00000001271	Integral membrane protein 2B.	annotation not available	0.695
ITM2B	ENSSARP00000001368	ENSSARP00000001345	ENSSARP00000001368	Integral membrane protein 2B.	annotation not available	0.818
ITM2B	ENSSARP00000004404	ENSSARP00000001345	ENSSARP00000004404	Integral membrane protein 2B.	annotation not available	0.797
ITM2B	ENSSARP00000004844	ENSSARP00000001345	ENSSARP00000004844	Integral membrane protein 2B.	annotation not available	0.941
ITM2B	ENSSARP00000005121	ENSSARP00000001345	ENSSARP00000005121	Integral membrane protein 2B.	annotation not available	0.654