PHB protein (Sorex araneus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PHB

Prohibitin. (269 aa)

Predicted Functional Partners:

STOML2

0.988

C1QBP

0.975

NDUFS3

0.966

ENSSARP00000010964

0.965

ENSSARP00000007775

0.962

ENSSARP00000000156

0.944

RB1

0.941

VDAC2

0.927

TP53

0.925

RAF1

0.916

Your Current Organism:

Sorex araneus

NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1QBP	PHB	ENSSARP00000008859	ENSSARP00000001422	Complement C1q binding protein.	Prohibitin.	0.975
C1QBP	STOML2	ENSSARP00000008859	ENSSARP00000011216	Complement C1q binding protein.	Stomatin like 2.	0.712
ENSSARP00000000156	PHB	ENSSARP00000000156	ENSSARP00000001422	annotation not available	Prohibitin.	0.944
ENSSARP00000000156	RB1	ENSSARP00000000156	ENSSARP00000001387	annotation not available	RB transcriptional corepressor 1.	0.999
ENSSARP00000000156	TP53	ENSSARP00000000156	ENSSARP00000005616	annotation not available	Tumor protein p53.	0.978
ENSSARP00000007775	ENSSARP00000010964	ENSSARP00000007775	ENSSARP00000010964	annotation not available	annotation not available	0.928
ENSSARP00000007775	NDUFS3	ENSSARP00000007775	ENSSARP00000006579	annotation not available	NADH:ubiquinone oxidoreductase core subunit S3.	0.439
ENSSARP00000007775	PHB	ENSSARP00000007775	ENSSARP00000001422	annotation not available	Prohibitin.	0.962
ENSSARP00000007775	STOML2	ENSSARP00000007775	ENSSARP00000011216	annotation not available	Stomatin like 2.	0.707
ENSSARP00000007775	VDAC2	ENSSARP00000007775	ENSSARP00000010093	annotation not available	Voltage dependent anion channel 2.	0.684
ENSSARP00000010964	ENSSARP00000007775	ENSSARP00000010964	ENSSARP00000007775	annotation not available	annotation not available	0.928
ENSSARP00000010964	PHB	ENSSARP00000010964	ENSSARP00000001422	annotation not available	Prohibitin.	0.965
ENSSARP00000010964	STOML2	ENSSARP00000010964	ENSSARP00000011216	annotation not available	Stomatin like 2.	0.663
ENSSARP00000010964	VDAC2	ENSSARP00000010964	ENSSARP00000010093	annotation not available	Voltage dependent anion channel 2.	0.940
NDUFS3	ENSSARP00000007775	ENSSARP00000006579	ENSSARP00000007775	NADH:ubiquinone oxidoreductase core subunit S3.	annotation not available	0.439
NDUFS3	PHB	ENSSARP00000006579	ENSSARP00000001422	NADH:ubiquinone oxidoreductase core subunit S3.	Prohibitin.	0.966
NDUFS3	STOML2	ENSSARP00000006579	ENSSARP00000011216	NADH:ubiquinone oxidoreductase core subunit S3.	Stomatin like 2.	0.531
NDUFS3	VDAC2	ENSSARP00000006579	ENSSARP00000010093	NADH:ubiquinone oxidoreductase core subunit S3.	Voltage dependent anion channel 2.	0.568
PHB	C1QBP	ENSSARP00000001422	ENSSARP00000008859	Prohibitin.	Complement C1q binding protein.	0.975
PHB	ENSSARP00000000156	ENSSARP00000001422	ENSSARP00000000156	Prohibitin.	annotation not available	0.944