STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE2Spire type actin nucleation factor 2. (604 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 0.904
ENSSARP00000004485
annotation not available
    
 0.863
FMN2
Formin 2.
    
 0.863
ENSSARP00000012065
annotation not available
    
 0.863
PLCG1
Phospholipase C gamma 1.
    
 0.848
MYO5A
Myosin VA.
   
 0.813
MYO5C
Myosin VC.
   
 0.813
NCK1
NCK adaptor protein 1.
    
 0.798
NCK2
NCK adaptor protein 2.
    
 0.798
ENSSARP00000008071
annotation not available
   
 0.786
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.