Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE2Spire type actin nucleation factor 2. (604 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.917
TCF25
Transcription factor 25.
 
  
 0.863
PLCG1
Phospholipase C gamma 1.
    
 0.863
MYO5A
Myosin VA.
   
 0.852
MYO5C
Myosin VC.
   
 0.852
NCK1
NCK adaptor protein 1.
    
 0.766
NCK2
NCK adaptor protein 2.
    
 0.766
VAV3
Vav guanine nucleotide exchange factor 3.
   
 0.763
ZAP70
Zeta chain of T cell receptor associated protein kinase 70.
   
 0.763
ENSSARP00000006489
annotation not available
   
 0.763
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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