Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RUBCNRubicon autophagy regulator. (945 aa)    
Predicted Functional Partners:
UVRAG
UV radiation resistance associated.
    
 
 0.988
PIK3R4
Phosphoinositide-3-kinase regulatory subunit 4.
    
 
 0.986
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 
 0.977
ENSSARP00000000332
annotation not available
    
 
 0.972
EGFR
Epidermal growth factor receptor.
    
 
 0.941
ENSSARP00000002146
annotation not available
    
 
 0.831
RANBP2
RAN binding protein 2.
    
   0.819
TOP2B
DNA topoisomerase II beta.
    
   0.780
ENSSARP00000013016
annotation not available
   
 
 0.628
VPS39
VPS39 subunit of HOPS complex.
   
 
 0.624
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.