STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase II binding protein 1. (1475 aa)    
Predicted Functional Partners:
BRCA1
BRCA1 DNA repair associated.
   
 0.999
ENSSARP00000011203
annotation not available
   
 0.997
BRIP1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.996
ATRIP
ATR interacting protein.
    
 0.994
TICRR
TOPBP1 interacting checkpoint and replication regulator.
    
 
 0.992
ATR
ATR serine/threonine kinase.
    
 0.990
CDC45
Cell division cycle 45.
   
 0.990
GINS4
GINS complex subunit 4.
    
 0.987
NBN
Nibrin.
    
 0.985
ENSSARP00000004303
annotation not available
   
 0.984
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.