GRB10 protein (Sorex araneus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

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[Homology]

Score

GRB10

Growth factor receptor bound protein 10. (573 aa)

Predicted Functional Partners:

ENSSARP00000004095

0.987

PIK3R1

0.984

EGFR

0.969

ENSSARP00000003522

0.962

ENSSARP00000006875

0.940

PIK3CA

0.938

ENSSARP00000008126

0.923

IRS1

0.839

ENSSARP00000000040

0.795

PLAG1

0.795

Your Current Organism:

Sorex araneus

NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ENSSARP00000000040	ENSSARP00000000687	ENSSARP00000000040	Epidermal growth factor receptor.	annotation not available	0.899
EGFR	ENSSARP00000003522	ENSSARP00000000687	ENSSARP00000003522	Epidermal growth factor receptor.	annotation not available	0.959
EGFR	ENSSARP00000004095	ENSSARP00000000687	ENSSARP00000004095	Epidermal growth factor receptor.	annotation not available	0.937
EGFR	ENSSARP00000008126	ENSSARP00000000687	ENSSARP00000008126	Epidermal growth factor receptor.	annotation not available	0.906
EGFR	GRB10	ENSSARP00000000687	ENSSARP00000001732	Epidermal growth factor receptor.	Growth factor receptor bound protein 10.	0.969
EGFR	IRS1	ENSSARP00000000687	ENSSARP00000000747	Epidermal growth factor receptor.	Insulin receptor substrate 1.	0.953
EGFR	PIK3CA	ENSSARP00000000687	ENSSARP00000008011	Epidermal growth factor receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.	0.999
EGFR	PIK3R1	ENSSARP00000000687	ENSSARP00000000857	Epidermal growth factor receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.998
ENSSARP00000000040	EGFR	ENSSARP00000000040	ENSSARP00000000687	annotation not available	Epidermal growth factor receptor.	0.899
ENSSARP00000000040	ENSSARP00000003522	ENSSARP00000000040	ENSSARP00000003522	annotation not available	annotation not available	0.476
ENSSARP00000000040	ENSSARP00000004095	ENSSARP00000000040	ENSSARP00000004095	annotation not available	annotation not available	0.543
ENSSARP00000000040	ENSSARP00000008126	ENSSARP00000000040	ENSSARP00000008126	annotation not available	annotation not available	0.826
ENSSARP00000000040	GRB10	ENSSARP00000000040	ENSSARP00000001732	annotation not available	Growth factor receptor bound protein 10.	0.795
ENSSARP00000000040	PIK3CA	ENSSARP00000000040	ENSSARP00000008011	annotation not available	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.	0.816
ENSSARP00000000040	PIK3R1	ENSSARP00000000040	ENSSARP00000000857	annotation not available	Phosphoinositide-3-kinase regulatory subunit 1.	0.426
ENSSARP00000003522	EGFR	ENSSARP00000003522	ENSSARP00000000687	annotation not available	Epidermal growth factor receptor.	0.959
ENSSARP00000003522	ENSSARP00000000040	ENSSARP00000003522	ENSSARP00000000040	annotation not available	annotation not available	0.476
ENSSARP00000003522	ENSSARP00000008126	ENSSARP00000003522	ENSSARP00000008126	annotation not available	annotation not available	0.795
ENSSARP00000003522	GRB10	ENSSARP00000003522	ENSSARP00000001732	annotation not available	Growth factor receptor bound protein 10.	0.962
ENSSARP00000003522	IRS1	ENSSARP00000003522	ENSSARP00000000747	annotation not available	Insulin receptor substrate 1.	0.513