Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HIPK3Homeodomain interacting protein kinase 3. (1051 aa)    
Predicted Functional Partners:
TP53
Tumor protein p53.
    
 0.986
RASSF5
Ras association domain family member 5.
    
 0.915
HIPK1
Homeodomain interacting protein kinase 1.
   
   0.900
SUMO1
Small ubiquitin-related modifier 1-like.
    
 0.725
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.724
MECP2
methyl-CpG binding protein 2.
    
 0.696
ENSSARP00000000712
annotation not available
   
   0.682
SRSF5
Serine and arginine rich splicing factor 5.
    
 
 0.679
ENSSARP00000004832
annotation not available
   
    0.664
ENSSARP00000006020
annotation not available
    
 
 0.658
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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