Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H1-3H1.3 linker histone, cluster member. (221 aa)    
Predicted Functional Partners:
CDK1
Cyclin dependent kinase 1.
   
 
 0.821
CCNE1
Cyclin E1.
    
   0.790
HMGB1
High mobility group box 1.
    
 0.733
HP1BP3
Heterochromatin protein 1 binding protein 3.
   
 0.719
H2AZ2
Histone H2A.V.
   
 
 0.697
CDK4
Cyclin dependent kinase 4.
   
 
 0.665
CCNA2
Cyclin A2.
    
 
 0.645
ENSSARP00000008890
annotation not available
    
 0.617
RPL3
Ribosomal protein L3.
    
   0.590
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
    
 
 0.589
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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