Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ESR2Estrogen receptor 2. (530 aa)    
Predicted Functional Partners:
ESR1
Estrogen receptor 1.
    
0.999
NCOA3
Nuclear receptor coactivator 3.
    
 0.998
MED1
Mediator complex subunit 1.
    
 0.997
NCOA1
Nuclear receptor coactivator 1.
    
 0.997
NCOA2
Nuclear receptor coactivator 2.
    
 0.995
AKT2
AKT serine/threonine kinase 2.
    
 0.969
ENSSARP00000010428
annotation not available
    
 0.968
PTGES3
Prostaglandin E synthase 3.
   
 0.964
YES1
YES proto-oncogene 1, Src family tyrosine kinase.
    
 0.962
ENSSARP00000005728
annotation not available
    
 0.946
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
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