Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLEKPleckstrin. (347 aa)    
Predicted Functional Partners:
MCF2
MCF.2 cell line derived transforming sequence.
      
 0.834
OSBP
Oxysterol binding protein.
      
 0.747
CNN1
Calponin 1.
     
 0.704
BTK
Bruton tyrosine kinase.
   
  
 0.699
FLNA
Filamin A.
     
 0.669
TYROBP
TYRO protein tyrosine kinase binding protein.
   
  
 0.660
PLCD1
Phospholipase C delta 1.
      
 0.656
RICTOR
RPTOR independent companion of MTOR complex 2.
      
 0.641
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2.
      
 0.631
CNN3
Calponin 3.
     
 0.628
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.