STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1152 aa)    
Predicted Functional Partners:
DHH
Desert hedgehog signaling molecule.
   
 0.999
ENSSARP00000008254
annotation not available
    
 0.993
ENSSARP00000013107
annotation not available
    
 0.993
CDON
Cell adhesion associated, oncogene regulated.
    
 0.991
ENSSARP00000004629
annotation not available
    
 0.976
SMURF2
SMAD specific E3 ubiquitin protein ligase 2.
    
 0.958
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.958
LRP2
LDL receptor related protein 2.
     
 0.871
SUFU
SUFU negative regulator of hedgehog signaling.
    
 
 0.822
ENSSARP00000005997
annotation not available
    
 0.770
Your Current Organism:
Sorex araneus
NCBI taxonomy Id: 42254
Other names: Eurasian shrew, European shrew, S. araneus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.