STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45296.1COG:COG1053: Succinate dehydrogenase/fumarate reductase flavoprotein subunit [Energy production and conversion]; Pfam:PF00890:FAD binding domain; Pfam:PF00890:FAD binding domain; SUPERFAMILY:SSF51905:No Description. (562 aa)    
Predicted Functional Partners:
AHY45297.1
TIGRFAM:TIGR00384:Succinate dehydrogenase/fumarate reductase iron-sulphur protein; COG:COG0479: Succinate dehydrogenase/fumarate reductase Fe-S protein subunit [Energy production and conversion]; Pfam:PF13085:Succinate dehydogenase/fumarate reductase N-terminal; ProSitePatterns:PS00197:2Fe-2S ferredoxin, iron-sulphur binding site; ProSiteProfiles:PS51085:2Fe-2S ferredoxin-type domain; SUPERFAMILY:SSF54292:2Fe-2S ferredoxin-type domain.
 0.999
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 0.994
sucC
sucCoAbeta: succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.987
AHY45587.1
Respiratory-chain NADH dehydrogenase 24 Kd subunit; COG:COG3411: Ferredoxin [Energy production and conversion]; Pfam:PF01257:Thioredoxin-like 2Fe-2S ferredoxin; SUPERFAMILY:SSF52833:Thioredoxin-like fold.
  
 
 0.986
sucD
sucCoAalpha: succinate-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.986
AHY47475.1
TIGRFAM:TIGR00722:Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; COG:COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class I N-terminal domain [Energy production and conversion]; Pfam:PF05681:Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; ttdA_fumA_fumB.
  
 
 0.959
AHY47476.1
TIGRFAM:TIGR00723:Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; COG:COG1838: Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain [Energy production and conversion]; Pfam:PF05683:Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; SUPERFAMILY:SSF117457:Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; ttdB_fumA_fumB.
  
 
 0.959
AHY45295.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
 
 
 
 0.952
AHY45372.1
nadC: nicotinate-nucleotide diphosphorylase (carboxylating); TIGRFAM:TIGR00078:Nicotinate-nucleotide pyrophosphorylase; COG:COG0157: Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Pfam:PF01729:Quinolinate phosphoribosyl transferase, C-terminal; PIRSF:PIRSF006250:Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD; SUPERFAMILY:SSF51690:Quinolinate phosphoribosyl transferase, C-terminal;KEGG: 00760; MetaCyc: PWY-5653; UniPathway: UPA00253; Belongs to the NadC/ModD family.
   
 0.936
AHY45918.1
COG:COG1012: NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Pfam:PF00171:Aldehyde dehydrogenase domain; Pfam:PF00171:Aldehyde dehydrogenase domain; SUPERFAMILY:SSF53720:Aldehyde/histidinol dehydrogenase.
   
 0.927
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (28%) [HD]
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