AHY45303.1 protein (Rubrobacter radiotolerans)

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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co-expression

protein homology

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Score

AHY45303.1

Hypothetical Protein; Ab initio prediction:Prodigal:2.60. (210 aa)

Predicted Functional Partners:

AHY45302.1

0.773

AHY45301.1

0.536

Your Current Organism:

Rubrobacter radiotolerans

NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHY45301.1	AHY45302.1	RradSPS_0018	RradSPS_0019	COG:COG1714: Predicted membrane protein/domain [Function unknown]; Pfam:PF06271:RDD; Pfam:PF06271:RDD.	COG:COG0300: Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; PIRSF:PIRSF000126:Short-chain dehydrogenase/reductase SDR; PRINTS:PR00081:Glucose/ribitol dehydrogenase; ProSitePatterns:PS00061:Short-chain dehydrogenase/reductase, conserved site; SMART:SM00822:Polyketide synthase/Fatty acid synthase, KR; SUPERFAMILY:SSF51735:No Description; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.548
AHY45301.1	AHY45303.1	RradSPS_0018	RradSPS_0020	COG:COG1714: Predicted membrane protein/domain [Function unknown]; Pfam:PF06271:RDD; Pfam:PF06271:RDD.	Hypothetical Protein; Ab initio prediction:Prodigal:2.60.	0.536
AHY45302.1	AHY45301.1	RradSPS_0019	RradSPS_0018	COG:COG0300: Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; PIRSF:PIRSF000126:Short-chain dehydrogenase/reductase SDR; PRINTS:PR00081:Glucose/ribitol dehydrogenase; ProSitePatterns:PS00061:Short-chain dehydrogenase/reductase, conserved site; SMART:SM00822:Polyketide synthase/Fatty acid synthase, KR; SUPERFAMILY:SSF51735:No Description; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	COG:COG1714: Predicted membrane protein/domain [Function unknown]; Pfam:PF06271:RDD; Pfam:PF06271:RDD.	0.548
AHY45302.1	AHY45303.1	RradSPS_0019	RradSPS_0020	COG:COG0300: Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; PIRSF:PIRSF000126:Short-chain dehydrogenase/reductase SDR; PRINTS:PR00081:Glucose/ribitol dehydrogenase; ProSitePatterns:PS00061:Short-chain dehydrogenase/reductase, conserved site; SMART:SM00822:Polyketide synthase/Fatty acid synthase, KR; SUPERFAMILY:SSF51735:No Description; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Hypothetical Protein; Ab initio prediction:Prodigal:2.60.	0.773
AHY45303.1	AHY45301.1	RradSPS_0020	RradSPS_0018	Hypothetical Protein; Ab initio prediction:Prodigal:2.60.	COG:COG1714: Predicted membrane protein/domain [Function unknown]; Pfam:PF06271:RDD; Pfam:PF06271:RDD.	0.536
AHY45303.1	AHY45302.1	RradSPS_0020	RradSPS_0019	Hypothetical Protein; Ab initio prediction:Prodigal:2.60.	COG:COG0300: Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; Pfam:PF00106:Short-chain dehydrogenase/reductase SDR; PIRSF:PIRSF000126:Short-chain dehydrogenase/reductase SDR; PRINTS:PR00081:Glucose/ribitol dehydrogenase; ProSitePatterns:PS00061:Short-chain dehydrogenase/reductase, conserved site; SMART:SM00822:Polyketide synthase/Fatty acid synthase, KR; SUPERFAMILY:SSF51735:No Description; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.773

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

25

PPI enrichment p-value:

2.6e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

10 of 24

1.76

4.23

5.88e-14

GO:0006520

Cellular amino acid metabolic process

11 of 137

1.05

1.39

6.30e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 257

0.78

0.8

1.71e-07

GO:0006139

Nucleobase-containing compound metabolic process

11 of 277

0.74

0.75

3.14e-07

GO:1901566

Organonitrogen compound biosynthetic process

11 of 310

0.69

0.67

9.69e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

10 of 24

1.76

4.29

2.88e-14

GO:0016874

Ligase activity

11 of 72

1.33

2.36

7.81e-13

GO:0002161

aminoacyl-tRNA editing activity

3 of 6

1.84

1.63

0.00042

GO:0005524

ATP binding

11 of 175

0.94

1.13

4.13e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 592

0.41

0.34

0.0027

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:342

tRNA aminoacylation

9 of 16

1.89

4.6

2.65e-13

CL:362

Aminoacyl-tRNA synthetase, class I, conserved site

5 of 5

2.14

3.31

1.28e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pto00970

Aminoacyl-tRNA biosynthesis

10 of 24

1.76

4.4

6.27e-15

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

10 of 24

1.76

4.37

9.60e-15

KW-0436

Ligase

11 of 62

1.39

2.67

8.61e-14

KW-0648

Protein biosynthesis

8 of 35

1.5

2.59

1.33e-09

KW-0067

ATP-binding

9 of 119

1.02

1.21

2.35e-07

KW-0963

Cytoplasm

6 of 94

0.95

0.83

0.00053

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08264

Anticodon-binding domain of tRNA ligase

3 of 3

2.14

1.53

0.0012

PF09334

tRNA synthetases class I (M)

3 of 4

2.02

1.49

0.0012

PF03129

Anticodon binding domain

2 of 3

1.97

0.78

0.0334

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

5 of 6

2.07

2.89

8.86e-07

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

5 of 6

2.07

2.89

8.86e-07

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

7 of 29

1.53

2.2

3.86e-07

IPR013155

Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding

3 of 3

2.14

1.61

0.00082

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 3

2.14

1.61

0.00082

(more ...)

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