STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45403.1Hypothetical Protein; Ab initio prediction:Prodigal:2.60; SUPERFAMILY:SSF52418:Glycosyl transferase, family 3. (69 aa)    
Predicted Functional Partners:
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.907
trpB-2
trpB: tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
  
 0.705
trpF
COG:COG0135: Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Pfam:PF00697:N-(5'phosphoribosyl) anthranilate isomerase (PRAI) like domain; Hamap:MF_00135:N-(5'phosphoribosyl) anthranilate isomerase (PRAI) like domain; Pfam:PF00697:N-(5'phosphoribosyl) anthranilate isomerase (PRAI) like domain; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel; Belongs to the TrpF family.
  
  
 0.705
trpA
trpA: tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
  
 0.704
AHY47161.1
COG:COG0134: Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Pfam:PF00218:Indole-3-glycerol phosphate synthase; Pfam:PF00218:Indole-3-glycerol phosphate synthase; ProSitePatterns:PS00614:Indole-3-glycerol phosphate synthase, conserved site; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel; Belongs to the TrpC family.
  
  
 0.704
AHY47163.1
Glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; TIGRFAM:TIGR00566:Anthranilate synthase/para-aminobenzoate synthase like domain; COG:COG0512: Anthranilate/para-aminobenzoate synthases component II [Amino acid transport and metabolism / Coenzyme metabolism]; Pfam:PF00117:Glutamine amidotransferase; PRINTS:PR00097:Anthranilate synthase component II signature; ProSiteProfiles:PS51273:Glutamine amidotransferase; SUPERFAMILY:SSF52317:No Description;KEGG: 00400; MetaCyc: PWY-5958; UniPathway: UPA00035; trpG_papA.
  
  
 0.704
hisI
TIGRFAM:TIGR03188:Phosphoribosyl-ATP pyrophosphohydrolase; COG:COG0139: Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Pfam:PF01502:Phosphoribosyl-AMP cyclohydrolase domain; Hamap:MF_01020:Phosphoribosyl-ATP pyrophosphohydrolase; SUPERFAMILY:SSF141734:No Description;KEGG: 00340; UniPathway: UPA00031; histidine_hisI; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.581
AHY46506.1
COG:COG0077: Prephenate dehydratase [Amino acid transport and metabolism]; Pfam:PF00800:Prephenate dehydratase; Pfam:PF00800:Prephenate dehydratase; PIRSF:PIRSF001500:Bifunctional P-protein, chorismate mutase/prephenate dehydratase; ProSiteProfiles:PS51168:Chorismate mutase; SMART:SM00830:Chorismate mutase; SUPERFAMILY:SSF53850:No Description.
  
  
 0.575
AHY46111.1
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
  
  
 0.495
hisC
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Hamap:MF_01023:Histidinol-phosphate aminotransferase family; Pfam:PF00155:Aminotransferase, class I/classII; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 0.495
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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