STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45420.1COG:COG1414: Transcriptional regulator [Transcription]; Pfam:PF01614:Transcription regulator IclR, C-terminal; Pfam:PF01614:Transcription regulator IclR, C-terminal; ProSiteProfiles:PS51077:Transcription regulator IclR, N-terminal; SMART:SM00346:Transcription regulator IclR, N-terminal; SUPERFAMILY:SSF55781:No Description. (216 aa)    
Predicted Functional Partners:
leuC
leuC: 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.660
leuD
leuD: 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
    0.624
AHY46202.1
COG:COG2049: Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Pfam:PF02682:Allophanate hydrolase subunit 1; Pfam:PF02682:Allophanate hydrolase subunit 1; SMART:SM00796:Allophanate hydrolase subunit 1; SUPERFAMILY:SSF50891:Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain.
  
    0.594
AHY45421.1
COG:COG4106: Trans-aconitate methyltransferase [General function prediction only]; Pfam:PF12847:Methyltransferase domain; Pfam:PF12847:Methyltransferase domain; SUPERFAMILY:SSF53335:No Description.
       0.537
AHY45422.1
Methyltransferase domain; COG:COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Pfam:PF08242:Methyltransferase type 12; SUPERFAMILY:SSF53335:No Description.
       0.537
AHY46203.1
Biotin-dependent carboxylase uncharacterized domain; TIGRFAM:TIGR00724:Allophanate hydrolase subunit 2; COG:COG1984: Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Pfam:PF02626:Allophanate hydrolase subunit 2; SMART:SM00797:Allophanate hydrolase subunit 2; SUPERFAMILY:SSF50891:Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain; urea_amlyse_rel.
  
    0.515
AHY46353.1
COG:COG3181: Uncharacterized protein conserved in bacteria [Function unknown]; Pfam:PF03401:Bordetella uptake gene; Pfam:PF03401:Bordetella uptake gene; PIRSF:PIRSF017082:Bordetella uptake gene; SUPERFAMILY:SSF53850:No Description.
 
  
 0.465
trpS
trpS: tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.449
AHY46431.1
Helix-turn-helix domain; COG:COG3620: Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Pfam:PF13560:Helix-turn-helix domain; ProSiteProfiles:PS50943:Helix-turn-helix; SMART:SM00530:Helix-turn-helix; SUPERFAMILY:SSF47413:Lambda repressor-like, DNA-binding domain.
  
  
 0.423
AHY46017.1
MacB-like periplasmic core domain; COG:COG4591: ABC-type transport system involved in lipoprotein release permease component [Cell envelope biogenesis outer membrane]; Pfam:PF12704:MacB-like periplasmic core domain.
  
    0.405
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.