STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
mutL-2Mutl: DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (530 aa)    
Predicted Functional Partners:
AHY45441.1
mutS1: DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA.
 
 0.993
mutL
Mutl: DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
  
 
0.915
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
   
 0.783
AHY46467.1
TIGRFAM:TIGR00614:DNA helicase, ATP-dependent, RecQ type; COG:COG0514: Superfamily II DNA helicase [DNA replication recombination and repair]; Pfam:PF00570:HRDC domain; ProSitePatterns:PS00690:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; ProSiteProfiles:PS51194:Helicase, C-terminal; SMART:SM00487:Helicase, superfamily 1/2, ATP-binding domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; recQ_fam.
  
 0.635
AHY45285.1
Dnan: DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
   
 0.621
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.615
uvrA
Uvra: excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
    
 0.615
AHY46822.1
TIGRFAM:TIGR00608:RadC protein; COG:COG2003: DNA repair proteins [DNA replication recombination and repair]; Pfam:PF04002:RadC-like JAB domain; ProSitePatterns:PS01302:Uncharacterised protein family UPF0758, conserved site; Belongs to the UPF0758 family.
 
   
 0.580
AHY45440.1
TIGRFAM:TIGR03718:Integral membrane protein TerC, riboswitch-linked; COG:COG0861: Membrane protein TerC possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Pfam:PF03741:Integral membrane protein TerC; R_switched_Alx.
  
    0.551
uvrC
uvrC: excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.504
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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