STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trpBPyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (448 aa)    
Predicted Functional Partners:
trpA
trpA: tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.997
AHY47161.1
COG:COG0134: Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Pfam:PF00218:Indole-3-glycerol phosphate synthase; Pfam:PF00218:Indole-3-glycerol phosphate synthase; ProSitePatterns:PS00614:Indole-3-glycerol phosphate synthase, conserved site; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel; Belongs to the TrpC family.
 
 
 0.977
trpB-2
trpB: tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
0.922
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
  0.904
AHY45436.1
pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase; TIGRFAM:TIGR00473:CDP-diacylglycerol--serine O-phosphatidyltransferase; COG:COG1183: Phosphatidylserine synthase [Lipid metabolism]; Pfam:PF01066:CDP-alcohol phosphatidyltransferase; ProSitePatterns:PS00379:CDP-alcohol phosphatidyltransferase;KEGG: 00260; KEGG: 00564; MetaCyc: PWY-5669; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
AHY46162.1
Glyoxalase-like domain; COG:COG0346: Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Pfam:PF12681:Glyoxalase-like domain; ProSitePatterns:PS00934:Glyoxalase I, conserved site; SUPERFAMILY:SSF54593:No Description.
     
  0.800
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
     
  0.800
AHY47282.1
Glyoxalase-like domain; COG:COG0346: Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Pfam:PF12681:Glyoxalase-like domain; ProSitePatterns:PS00934:Glyoxalase I, conserved site; SUPERFAMILY:SSF54593:No Description.
     
  0.800
AHY47849.1
COG:COG2021: Homoserine acetyltransferase [Amino acid transport and metabolism]; Pfam:PF12697:Alpha/beta hydrolase family; Pfam:PF12697:Alpha/beta hydrolase family; PIRSF:PIRSF000443:Homoserine acetyltransferase; SUPERFAMILY:SSF53474:No Description; Belongs to the AB hydrolase superfamily. MetX family.
     
  0.800
AHY45463.1
COG:COG1682: ABC-type polysaccharide/polyol phosphate export systems permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis outer membrane]; Pfam:PF01061:ABC-2 type transporter; Pfam:PF01061:ABC-2 type transporter; PIRSF:PIRSF006648:No Description; ProSiteProfiles:PS51012:ABC-2.
       0.479
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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