STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45485.1COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00482:DNA-directed DNA polymerase, family A, palm domain; SUPERFAMILY:SSF56672:No Description. (591 aa)    
Predicted Functional Partners:
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
 
 
0.960
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.606
AHY45486.1
Peptidase family M50; COG:COG1994: Zn-dependent proteases [General function prediction only]; Pfam:PF02163:Peptidase M50; PIRSF:PIRSF006404:Uncharacterised conserved protein UCP006404, peptidase M50/CBS; ProSiteProfiles:PS51371:Cystathionine beta-synthase, core; SMART:SM00116:Cystathionine beta-synthase, core; SUPERFAMILY:SSF54631:No Description; Belongs to the peptidase M50B family.
  
  
 0.572
AHY45487.1
Periplasmic binding protein; COG:COG0614: ABC-type Fe3+-hydroxamate transport system periplasmic component [Inorganic ion transport and metabolism]; Pfam:PF01497:ABC transporter periplasmic binding domain; ProSiteProfiles:PS50983:ABC transporter periplasmic binding domain; SUPERFAMILY:SSF53807:No Description.
       0.551
AHY45488.1
TIGRFAM:TIGR00277:Uncharacterised domain HDIG; COG:COG1418: Predicted HD superfamily hydrolase [General function prediction only]; Pfam:PF01966:HD domain; SMART:SM00471:HD/PDEase domain; SUPERFAMILY:SSF109604:No Description;KEGG: 00230; KEGG: 00240.
       0.533
AHY47837.1
COG:COG0069: Glutamate synthase domain 2 [Amino acid transport and metabolism]; Pfam:PF01645:Glutamate synthase, central-C; ProSiteProfiles:PS51278:Glutamine amidotransferase type 2 domain; SUPERFAMILY:SSF51395:No Description;UniPathway: UPA00045.
      
 0.524
AHY45447.1
Sulfotransferase family; COG:COG3551: Uncharacterized protein conserved in bacteria [Function unknown]; Pfam:PF13469:Sulfotransferase family; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
  
 0.510
AHY47638.1
COG:COG0420: DNA repair exonuclease [DNA replication recombination and repair]; Pfam:PF12850:Calcineurin-like phosphoesterase superfamily domain; Pfam:PF12850:Calcineurin-like phosphoesterase superfamily domain; SUPERFAMILY:SSF56300:No Description.
   
 0.501
msrA
msrA: peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
  
 0.500
AHY45285.1
Dnan: DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiat [...]
 
 
 0.499
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.