STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45495.1TIGRFAM:TIGR00977:2-isopropylmalate synthase/homocitrate synthase-related; COG:COG0119: Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Pfam:PF00682:Pyruvate carboxyltransferase; ProSitePatterns:PS00815:Alpha-isopropylmalate/homocitrate synthase, conserved site; ProSiteProfiles:PS50991:Pyruvate carboxyltransferase; SMART:SM00917:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SUPERFAMILY:SSF51569:No Description;KEGG: 00966; LeuA_rel; Belongs to the alpha-IPM synthase/homocitrate synthase family. (541 aa)    
Predicted Functional Partners:
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 0.985
leuC
leuC: 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.978
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
  
 
0.977
leuD
leuD: 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.973
AHY46003.1
Dehydratase family; COG:COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Pfam:PF00920:Dihydroxy-acid/6-phosphogluconate dehydratase; SUPERFAMILY:SSF52016:Aconitase/3-isopropylmalate dehydratase, swivel;MetaCyc: PWY-5103; UniPathway: UPA00047; UniPathway: UPA00049; Belongs to the IlvD/Edd family.
 
 
 0.959
ilvD
TIGRFAM:TIGR00110:Dihydroxy-acid dehydratase; COG:COG0129: Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Pfam:PF00920:Dihydroxy-acid/6-phosphogluconate dehydratase; Hamap:MF_00012:Dihydroxy-acid dehydratase; ProSitePatterns:PS00886:Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site; SUPERFAMILY:SSF143975:No Description;KEGG: 00290; KEGG: 00770; MetaCyc: PWY-5103; UniPathway: UPA00047; UniPathway: UPA00049; Belongs to the IlvD/Edd family.
 
 
 0.957
AHY45321.1
accC: acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.936
AHY45737.1
COG:COG4770: Acetyl/propionyl-CoA carboxylase alpha subunit [Lipid metabolism]; Pfam:PF02786:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; Pfam:PF02786:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; ProSitePatterns:PS00866:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SMART:SM00878:Biotin carboxylase, C-terminal; SUPERFAMILY:SSF56059:No Description.
  
 
 0.936
AHY46201.1
accC: acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.936
AHY45707.1
AcCoA-C-Actrans: acetyl-CoA C-acetyltransferase; TIGRFAM:TIGR01930:Thiolase; COG:COG0183: Acetyl-CoA acetyltransferase [Lipid metabolism]; Pfam:PF00108:Thiolase, N-terminal; PIRSF:PIRSF000429:Thiolase; ProSitePatterns:PS00099:Thiolase, active site; SUPERFAMILY:SSF53901:Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.918
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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