STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
thrBthrB: homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)    
Predicted Functional Partners:
AHY45510.1
thrC: threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.998
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
 
 0.997
purM
TIGRFAM:TIGR00878:Phosphoribosylformylglycinamidine cyclo-ligase; COG:COG0150: Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Pfam:PF02769:AIR synthase-related protein, C-terminal domain; SUPERFAMILY:SSF56042:AIR synthase-related protein, C-terminal domain;KEGG: 00230; MetaCyc: PWY-6121; UniPathway: UPA00074.
 
    
 0.909
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
    
 0.881
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.879
AHY47788.1
Cobalamin-independent synthase, Catalytic domain; COG:COG0620: Methionine synthase II (cobalamin-independent) [Amino acid transport and metabolism]; Pfam:PF01717:Methionine synthase, vitamin-B12 independent; SUPERFAMILY:SSF51726:No Description;MetaCyc: PWY-702; UniPathway: UPA00051.
   
 
 0.861
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.854
AHY46330.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; TIGRFAM:TIGR01326:O-acetylhomoserine/O-acetylserine sulfhydrylase; COG:COG2873: O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Pfam:PF01053:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PIRSF:PIRSF001434:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; ProSitePatterns:PS00868:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00270; MetaCyc: PWY-5344; OAH_OAS_sulfhy.
    
  0.811
AHY47060.1
COG:COG0499: S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Pfam:PF05221:Adenosylhomocysteinase; Pfam:PF05221:Adenosylhomocysteinase; PIRSF:PIRSF001109:Adenosylhomocysteinase; SMART:SM00996:Adenosylhomocysteinase; SUPERFAMILY:SSF52283:No Description.
     
  0.800
AHY46331.1
TIGRFAM:TIGR00657:Aspartate kinase domain; COG:COG0527: Aspartokinases [Amino acid transport and metabolism]; Pfam:PF00696:Aspartate/glutamate/uridylate kinase; ProSitePatterns:PS00324:Aspartate kinase, conserved site; SUPERFAMILY:SSF53633:Aspartate/glutamate/uridylate kinase;KEGG: 00260; KEGG: 00270; KEGG: 00300; MetaCyc: PWY-2941; UniPathway: UPA00034; UniPathway: UPA00050; UniPathway: UPA00051; asp_kinases; Belongs to the aspartokinase family.
 
 
 0.791
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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