STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45510.1thrC: threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (365 aa)    
Predicted Functional Partners:
thrB
thrB: homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.998
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
  
 
 0.946
AHY45953.1
COG:COG2008: Threonine aldolase [Amino acid transport and metabolism]; Pfam:PF01212:Aromatic amino acid beta-eliminating lyase/threonine aldolase; Pfam:PF01212:Aromatic amino acid beta-eliminating lyase/threonine aldolase; PIRSF:PIRSF017617:Threonine aldolase; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
  
 0.938
AHY47837.1
COG:COG0069: Glutamate synthase domain 2 [Amino acid transport and metabolism]; Pfam:PF01645:Glutamate synthase, central-C; ProSiteProfiles:PS51278:Glutamine amidotransferase type 2 domain; SUPERFAMILY:SSF51395:No Description;UniPathway: UPA00045.
  
  
 0.744
leuD
leuD: 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
  
 0.737
AHY46331.1
TIGRFAM:TIGR00657:Aspartate kinase domain; COG:COG0527: Aspartokinases [Amino acid transport and metabolism]; Pfam:PF00696:Aspartate/glutamate/uridylate kinase; ProSitePatterns:PS00324:Aspartate kinase, conserved site; SUPERFAMILY:SSF53633:Aspartate/glutamate/uridylate kinase;KEGG: 00260; KEGG: 00270; KEGG: 00300; MetaCyc: PWY-2941; UniPathway: UPA00034; UniPathway: UPA00050; UniPathway: UPA00051; asp_kinases; Belongs to the aspartokinase family.
  
 
 0.690
AHY47938.1
TIGRFAM:TIGR00656:Aspartate kinase, monofunctional class; COG:COG0527: Aspartokinases [Amino acid transport and metabolism]; Pfam:PF00696:Aspartate/glutamate/uridylate kinase; PIRSF:PIRSF000726:Aspartate kinase, monofunctional class; ProSitePatterns:PS00324:Aspartate kinase, conserved site; SUPERFAMILY:SSF53633:Aspartate/glutamate/uridylate kinase;KEGG: 00260; KEGG: 00270; KEGG: 00300; MetaCyc: PWY-2941; UniPathway: UPA00034; UniPathway: UPA00050; UniPathway: UPA00051; asp_kin_monofn; Belongs to the aspartokinase family.
  
 
 0.690
ilvC
ilvC: ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.674
AHY46506.1
COG:COG0077: Prephenate dehydratase [Amino acid transport and metabolism]; Pfam:PF00800:Prephenate dehydratase; Pfam:PF00800:Prephenate dehydratase; PIRSF:PIRSF001500:Bifunctional P-protein, chorismate mutase/prephenate dehydratase; ProSiteProfiles:PS51168:Chorismate mutase; SMART:SM00830:Chorismate mutase; SUPERFAMILY:SSF53850:No Description.
  
  
 0.641
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.594
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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