STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45652.1Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COG:COG3290: Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Pfam:PF02518:Histidine kinase-like ATPase, ATP-binding domain; SMART:SM00387:Histidine kinase-like ATPase, ATP-binding domain; SUPERFAMILY:SSF55874:Histidine kinase-like ATPase, ATP-binding domain. (302 aa)    
Predicted Functional Partners:
AHY45891.1
TIGRFAM:TIGR00229:PAS domain; COG:COG0642: Signal transduction histidine kinase [Signal transduction mechanisms]; Pfam:PF02518:Histidine kinase-like ATPase, ATP-binding domain; PRINTS:PR00344:Signal transduction histidine kinase-related protein, C-terminal; ProSiteProfiles:PS50112:PAS domain; SMART:SM00387:Histidine kinase-like ATPase, ATP-binding domain; SUPERFAMILY:SSF55874:Histidine kinase-like ATPase, ATP-binding domain; sensory_box.
  
  
 0.921
AHY46909.1
TIGRFAM:TIGR00377:Anti-sigma factor antagonist; COG:COG1366: Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Pfam:PF01740:STAS domain; ProSiteProfiles:PS50801:STAS domain; SUPERFAMILY:SSF52091:STAS domain; ant_ant_sig; Belongs to the anti-sigma-factor antagonist family.
  
 
 0.836
AHY47729.1
TIGRFAM:TIGR00377:Anti-sigma factor antagonist; COG:COG1366: Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Pfam:PF01740:STAS domain; ProSiteProfiles:PS50801:STAS domain; SUPERFAMILY:SSF52091:STAS domain; ant_ant_sig; Belongs to the anti-sigma-factor antagonist family.
  
 
 0.836
AHY45508.1
TIGRFAM:TIGR00229:PAS domain; COG:COG2197: Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Pfam:PF13426:PAS domain; PRINTS:PR00038:Transcription regulator LuxR, C-terminal; ProSitePatterns:PS00622:Transcription regulator LuxR, C-terminal; ProSiteProfiles:PS50113:PAS-associated, C-terminal; SMART:SM00421:Transcription regulator LuxR, C-terminal; SUPERFAMILY:SSF55785:PAS domain; sensory_box.
  
  
 0.754
AHY46908.1
Stage II sporulation protein E (SpoIIE); COG:COG2208: Serine phosphatase RsbU regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Pfam:PF07228:Protein phosphatase 2C (PP2C)-like; SMART:SM00331:Protein phosphatase 2C (PP2C)-like; SUPERFAMILY:SSF55785:PAS domain.
  
 
 0.734
AHY46004.1
TIGRFAM:TIGR00229:PAS domain; COG:COG2200: FOG: EAL domain [Signal transduction mechanisms]; Pfam:PF00563:Diguanylate phosphodiesterase, EAL domain; ProSiteProfiles:PS50113:PAS-associated, C-terminal; SMART:SM00052:Diguanylate phosphodiesterase, EAL domain; SUPERFAMILY:SSF141868:Diguanylate phosphodiesterase, EAL domain; sensory_box.
  
 
 0.706
AHY46478.1
TIGRFAM:TIGR00229:PAS domain; COG:COG4585: Signal transduction histidine kinase [Signal transduction mechanisms]; Pfam:PF08448:PAS fold-4; ProSiteProfiles:PS50113:PAS-associated, C-terminal; SMART:SM00065:GAF domain; SUPERFAMILY:SSF55785:PAS domain; sensory_box.
  
  
 0.655
AHY46167.1
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; TIGRFAM:TIGR03551:CofH family; COG:COG1060: Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes [Coenzyme metabolism / General function prediction only]; Pfam:PF04055:Radical SAM; Hamap:MF_01612:CofH family; SMART:SM00729:Elongator protein 3/MiaB/NifB; SUPERFAMILY:SSF102114:No Description;KEGG: 00130; KEGG: 00270; KEGG: 00380; KEGG: 00740; KEGG: 00860; KEGG: 00900; KEGG: 00906; UniPathway: UPA00072.
   
    0.649
AHY45921.1
EAL domain; COG:COG2200: FOG: EAL domain [Signal transduction mechanisms]; Pfam:PF00563:Diguanylate phosphodiesterase, EAL domain; ProSiteProfiles:PS50883:Diguanylate phosphodiesterase, EAL domain; SMART:SM00052:Diguanylate phosphodiesterase, EAL domain; SUPERFAMILY:SSF141868:Diguanylate phosphodiesterase, EAL domain.
  
 
 0.636
AHY46220.1
GGDEF: diguanylate cyclase (GGDEF) domain; TIGRFAM:TIGR00254:GGDEF domain; COG:COG2199: FOG: GGDEF domain [Signal transduction mechanisms]; Pfam:PF00990:GGDEF domain; ProSiteProfiles:PS50113:PAS-associated, C-terminal; SMART:SM00267:GGDEF domain; SUPERFAMILY:SSF55073:Adenylyl cyclase class-3/4/guanylyl cyclase.
  
 
 0.636
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (24%) [HD]
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