STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metGmetG: methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (578 aa)    
Predicted Functional Partners:
leuS
TIGRFAM:TIGR00396:Leucine-tRNA ligase, bacterial/mitochondrial; COG:COG0495: Leucyl-tRNA synthetase [Translation ribosomal structure and biogenesis]; Pfam:PF13603:Leucyl-tRNA synthetase, editing domain; Hamap:MF_00049_B:Leucine-tRNA ligase, bacterial/mitochondrial; PRINTS:PR00985:Leucine-tRNA ligase, bacterial/mitochondrial; SUPERFAMILY:SSF52374:No Description;KEGG: 00290; KEGG: 00970; leuS_bact; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.996
pheS
pheS: phenylalanine--tRNA ligase, alpha subunit; TIGRFAM:TIGR00468:Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; COG:COG0016: Phenylalanyl-tRNA synthetase alpha subunit [Translation ribosomal structure and biogenesis]; Pfam:PF01409:Phenylalanyl-tRNA synthetase; Hamap:MF_00281:Phenylalanine-tRNA ligase alpha chain 1, bacterial; ProSiteProfiles:PS50862:Aminoacyl-tRNA synthetase, class II; SUPERFAMILY:SSF55681:No Description;KEGG: 00970.
 
 
 0.967
ileS
ileS: isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
 0.956
fmt
Fmt: methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.950
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
  
 
 0.945
argS
argS: arginine--tRNA ligase; TIGRFAM:TIGR00456:Arginine-tRNA ligase, class Ia; COG:COG0018: Arginyl-tRNA synthetase [Translation ribosomal structure and biogenesis]; Pfam:PF00750:Arginyl-tRNA synthetase, class Ia, core; Hamap:MF_00123:Arginine-tRNA ligase, class Ia; PRINTS:PR01038:Arginyl-tRNA synthetase, class Ia, core; ProSitePatterns:PS00178:Aminoacyl-tRNA synthetase, class I, conserved site; SMART:SM00836:DALR anticodon binding; SUPERFAMILY:SSF52374:No Description;KEGG: 00970; Reactome: REACT_71.
  
 0.937
proS
proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
 
 0.932
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.920
AHY47788.1
Cobalamin-independent synthase, Catalytic domain; COG:COG0620: Methionine synthase II (cobalamin-independent) [Amino acid transport and metabolism]; Pfam:PF01717:Methionine synthase, vitamin-B12 independent; SUPERFAMILY:SSF51726:No Description;MetaCyc: PWY-702; UniPathway: UPA00051.
    
 0.914
pheT
TIGRFAM:TIGR00472:Phenylalanine-tRNA ligase, class IIc, beta subunit, bacterial; COG:COG0072: Phenylalanyl-tRNA synthetase beta subunit [Translation ribosomal structure and biogenesis]; Pfam:PF03483:B3/B4 tRNA-binding domain; Hamap:MF_00283:Phenylalanine-tRNA ligase, class IIc, beta subunit, bacterial; ProSiteProfiles:PS51483:tRNA synthetase, B5-domain; SMART:SM00873:B3/B4 tRNA-binding domain; SUPERFAMILY:SSF56037:Phenylalanyl-tRNA synthetase, B3/B4;KEGG: 00970; pheT_bact.
  
  
 0.885
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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