STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45681.1COG:COG0071: Molecular chaperone (small heat shock protein) [Posttranslational modification protein turnover chaperones]; Pfam:PF00011:Alpha crystallin/Hsp20 domain; Pfam:PF00011:Alpha crystallin/Hsp20 domain; ProSiteProfiles:PS01031:Alpha crystallin/Hsp20 domain; SUPERFAMILY:SSF49764:HSP20-like chaperone; Belongs to the small heat shock protein (HSP20) family. (175 aa)    
Predicted Functional Partners:
AHY45682.1
COG:COG0542: ATPases with chaperone activity ATP-binding subunit [Posttranslational modification protein turnover chaperones]; Pfam:PF07724:ATPase, AAA-2; Pfam:PF07724:ATPase, AAA-2; PRINTS:PR00300:Chaperonin ClpA/B; ProSitePatterns:PS00871:Chaperonin ClpA/B; ProSiteProfiles:PS50151:UVR domain; SMART:SM01086:Clp ATPase, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the ClpA/ClpB family.
  
 
 0.754
AHY45387.1
Clp amino terminal domain; COG:COG0542: ATPases with chaperone activity ATP-binding subunit [Posttranslational modification protein turnover chaperones]; Pfam:PF02861:Clp, N-terminal; SUPERFAMILY:SSF81923:No Description.
  
 
 0.551
AHY45449.1
COG:COG0542: ATPases with chaperone activity ATP-binding subunit [Posttranslational modification protein turnover chaperones]; Pfam:PF07724:ATPase, AAA-2; Pfam:PF07724:ATPase, AAA-2; PRINTS:PR00300:Chaperonin ClpA/B; ProSitePatterns:PS00871:Chaperonin ClpA/B; ProSiteProfiles:PS50151:UVR domain; SMART:SM01086:Clp ATPase, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the ClpA/ClpB family.
  
 
 0.551
AHY47250.1
COG:COG0542: ATPases with chaperone activity ATP-binding subunit [Posttranslational modification protein turnover chaperones]; Pfam:PF07724:ATPase, AAA-2; Pfam:PF07724:ATPase, AAA-2; PRINTS:PR00300:Chaperonin ClpA/B; ProSitePatterns:PS00870:Chaperonin ClpA/B, conserved site; ProSiteProfiles:PS50151:UVR domain; SMART:SM01086:Clp ATPase, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the ClpA/ClpB family.
  
 
 0.551
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.545
AHY45680.1
TIGRFAM:TIGR01764:Excisionase/Xis, DNA-binding; COG:COG2452: Predicted site-specific integrase-resolvase [DNA replication recombination and repair]; Pfam:PF12728:Helix-turn-helix domain; SUPERFAMILY:SSF46955:DNA binding domain, putative.
       0.473
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
  
 0.463
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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