STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45737.1COG:COG4770: Acetyl/propionyl-CoA carboxylase alpha subunit [Lipid metabolism]; Pfam:PF02786:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; Pfam:PF02786:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; ProSitePatterns:PS00866:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain; ProSiteProfiles:PS50968:Biotin/lipoyl attachment; SMART:SM00878:Biotin carboxylase, C-terminal; SUPERFAMILY:SSF56059:No Description. (587 aa)    
Predicted Functional Partners:
AHY45731.1
COG:COG4799: Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Pfam:PF01039:Carboxyl transferase; Pfam:PF01039:Carboxyl transferase; PRINTS:PR01070:Acetyl-CoA carboxylase carboxyl transferase, beta subunit; ProSiteProfiles:PS50980:Acetyl-coenzyme A carboxyltransferase, N-terminal; SUPERFAMILY:SSF52096:No Description.
 
 0.999
AHY46912.1
COG:COG4799: Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Pfam:PF01039:Carboxyl transferase; Pfam:PF01039:Carboxyl transferase; ProSiteProfiles:PS50980:Acetyl-coenzyme A carboxyltransferase, N-terminal; SUPERFAMILY:SSF52096:No Description.
 
 0.978
AHY45320.1
BCCP: acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.971
AHY47153.1
Carboxyl transferase domain; COG:COG0777: Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Pfam:PF01039:Carboxyl transferase; PRINTS:PR01070:Acetyl-CoA carboxylase carboxyl transferase, beta subunit; ProSiteProfiles:PS50989:Acetyl-coenzyme A carboxyltransferase, C-terminal; SUPERFAMILY:SSF52096:No Description;MetaCyc: PWY-5744; UniPathway: UPA00655.
 0.969
AHY46205.1
Biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.967
accA
accA: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
  
 0.954
AHY45525.1
COG:COG0331: (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Pfam:PF00698:Acyl transferase; Pfam:PF00698:Acyl transferase; SMART:SM00827:Polyketide synthase, acyl transferase domain; SUPERFAMILY:SSF52151:Acyl transferase/acyl hydrolase/lysophospholipase.
  
 
 0.940
AHY46668.1
COG:COG0331: (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Pfam:PF00698:Acyl transferase; Pfam:PF00698:Acyl transferase; PIRSF:PIRSF000446:Malonyl CoA-acyl carrier protein transacylase; SMART:SM00827:Polyketide synthase, acyl transferase domain; SUPERFAMILY:SSF52151:Acyl transferase/acyl hydrolase/lysophospholipase.
  
 
 0.940
AHY45495.1
TIGRFAM:TIGR00977:2-isopropylmalate synthase/homocitrate synthase-related; COG:COG0119: Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Pfam:PF00682:Pyruvate carboxyltransferase; ProSitePatterns:PS00815:Alpha-isopropylmalate/homocitrate synthase, conserved site; ProSiteProfiles:PS50991:Pyruvate carboxyltransferase; SMART:SM00917:2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SUPERFAMILY:SSF51569:No Description;KEGG: 00966; LeuA_rel; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.936
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.936
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (26%) [HD]
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