STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45823.1Fpg: formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (279 aa)    
Predicted Functional Partners:
AHY45677.1
Fpg: formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
0.916
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
  
  
 0.870
AHY45822.1
Cof-subfamily: Cof-like hydrolase; TIGRFAM:TIGR00099:Cof protein; COG:COG0561: Predicted hydrolases of the HAD superfamily [General function prediction only]; Pfam:PF08282:HAD-like domain; SUPERFAMILY:SSF56784:HAD-like domain.
  
    0.739
AHY45537.1
TIGRFAM:TIGR00573:DNA polymerase III, epsilon subunit; COG:COG0322: Nuclease subunit of the excinuclease complex [DNA replication recombination and repair]; Pfam:PF00929:Exonuclease, RNase T/DNA polymerase III; ProSiteProfiles:PS50151:UVR domain; SMART:SM00479:Exonuclease; SUPERFAMILY:SSF53098:Ribonuclease H-like domain;KEGG: 00230; KEGG: 00240.
  
  
 0.588
coaE
TIGR00152: dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.523
AHY46710.1
Helix-turn-helix domain; COG:COG1426: Uncharacterized protein conserved in bacteria [Function unknown]; Pfam:PF13413:Helix-turn-helix domain.
  
     0.518
AHY45821.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
       0.499
AHY45824.1
Conserved repeat domain; TIGRFAM:TIGR01451:Domain of unknown function DUF11; COG:COG2931: RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis transport and catabolism]; Pfam:PF01345:Domain of unknown function DUF11; PRINTS:PR00313:NodO calcium binding signature; ProSitePatterns:PS00330:Hemolysin-type calcium-binding conserved site; ProSiteProfiles:PS51257:Prokaryotic membrane lipoprotein lipid attachment site profile.; SUPERFAMILY:SSF51120:Serralysin-like metalloprotease, C-terminal; B_ant_repeat.
       0.479
nth
Nth: endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.473
AHY45485.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00482:DNA-directed DNA polymerase, family A, palm domain; SUPERFAMILY:SSF56672:No Description.
  
  
 0.451
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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