STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiGthiS: thiamine biosynthesis protein ThiS; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (324 aa)    
Predicted Functional Partners:
AHY45868.1
TIGRFAM:TIGR02352:Glycine oxidase ThiO; COG:COG0665: Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Pfam:PF01266:FAD dependent oxidoreductase; PRINTS:PR01001:FAD-dependent glycerol-3-phosphate dehydrogenase; SUPERFAMILY:SSF51905:No Description;UniPathway: UPA00060; thiamin_ThiO.
 
 0.999
thiE
thiE: thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.999
AHY47427.1
ThiF family; COG:COG0476: Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Pfam:PF00899:UBA/THIF-type NAD/FAD binding fold; ProSiteProfiles:PS50206:Rhodanese-like domain; SMART:SM00450:Rhodanese-like domain; SUPERFAMILY:SSF69572:Molybdenum cofactor biosynthesis, MoeB.
 
 
 0.999
AHY45660.1
COG:COG0607: Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Pfam:PF00581:Rhodanese-like domain; Pfam:PF00581:Rhodanese-like domain; ProSiteProfiles:PS50206:Rhodanese-like domain; SMART:SM00450:Rhodanese-like domain; SUPERFAMILY:SSF52821:Rhodanese-like domain.
  
 
 0.998
AHY46167.1
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; TIGRFAM:TIGR03551:CofH family; COG:COG1060: Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes [Coenzyme metabolism / General function prediction only]; Pfam:PF04055:Radical SAM; Hamap:MF_01612:CofH family; SMART:SM00729:Elongator protein 3/MiaB/NifB; SUPERFAMILY:SSF102114:No Description;KEGG: 00130; KEGG: 00270; KEGG: 00380; KEGG: 00740; KEGG: 00860; KEGG: 00900; KEGG: 00906; UniPathway: UPA00072.
  
 
 0.998
thiE-2
thiE: thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.998
AHY47716.1
TIGRFAM:TIGR00097:Phosphomethylpyrimidine kinase type-2; COG:COG0351: Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme metabolism]; Pfam:PF08543:Phosphomethylpyrimidine kinase type-1; SUPERFAMILY:SSF53613:No Description;KEGG: 00730; UniPathway: UPA00060; HMP-P_kinase.
 
  
 0.998
AHY47426.1
COG:COG1977: Molybdopterin converting factor small subunit [Coenzyme metabolism]; Pfam:PF02597:ThiamineS/Molybdopterin converting factor subunit 1; Pfam:PF02597:ThiamineS/Molybdopterin converting factor subunit 1; SUPERFAMILY:SSF54285:Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp.
   
 
 0.931
thiM
thiM: hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
  
 0.922
AHY45867.1
COG:COG1310: Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Pfam:PF14464:Prokaryotic homologs of the JAB domain; SMART:SM00232:JAB1/Mov34/MPN/PAD-1; SUPERFAMILY:SSF102712:No Description.
 
 
 0.921
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.