STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45913.1COG:COG0685: 510-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Pfam:PF02219:Methylenetetrahydrofolate reductase; Pfam:PF02219:Methylenetetrahydrofolate reductase; SUPERFAMILY:SSF51730:No Description; Belongs to the methylenetetrahydrofolate reductase family. (298 aa)    
Predicted Functional Partners:
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.998
AHY45915.1
COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; PIRSF:PIRSF006487:Glycine cleavage system T protein; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
  
 
 0.961
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
  
 
 0.948
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
AHY45912.1
COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; PIRSF:PIRSF006487:Glycine cleavage system T protein; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
 
  
 0.921
folD
510-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.920
gcvT
gcvT: glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.912
AHY45658.1
thyX: thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.908
fhs
COG:COG2759: Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Pfam:PF01268:Formate-tetrahydrofolate ligase, FTHFS; Hamap:MF_01543:Formate-tetrahydrofolate ligase, FTHFS; Pfam:PF01268:Formate-tetrahydrofolate ligase, FTHFS; ProSitePatterns:PS00722:Formate-tetrahydrofolate ligase, FTHFS, conserved site; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the formate--tetrahydrofolate ligase family.
 
  
 0.896
AHY45911.1
FAD dependent oxidoreductase; COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01266:FAD dependent oxidoreductase; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
 
  
 0.821
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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