STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY45943.1MerR HTH family regulatory protein; COG:COG0789: Predicted transcriptional regulators [Transcription]; Pfam:PF13411:MerR HTH family regulatory protein; ProSitePatterns:PS00552:Transcription regulator HTH, MerR; ProSiteProfiles:PS50937:Transcription regulator HTH, MerR; SMART:SM00422:Transcription regulator HTH, MerR; SUPERFAMILY:SSF46955:DNA binding domain, putative. (155 aa)    
Predicted Functional Partners:
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
  
 0.960
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.917
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.859
AHY45944.1
Pfam:PF00643:Zinc finger, B-box; SUPERFAMILY:SSF57845:No Description.
  
    0.717
AHY48055.1
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; COG:COG0642: Signal transduction histidine kinase [Signal transduction mechanisms]; Pfam:PF02518:Histidine kinase-like ATPase, ATP-binding domain; PRINTS:PR00344:Signal transduction histidine kinase-related protein, C-terminal; SUPERFAMILY:SSF55874:Histidine kinase-like ATPase, ATP-binding domain.
 
 
 
 0.686
dnaJ-2
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.650
AHY47492.1
COG:COG0484: DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification protein turnover chaperones]; Pfam:PF00226:DnaJ domain; PRINTS:PR00625:DnaJ domain; ProSiteProfiles:PS50076:DnaJ domain; SMART:SM00271:DnaJ domain; SUPERFAMILY:SSF46565:DnaJ domain.
  
 
 0.650
AHY48017.1
COG:COG0484: DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification protein turnover chaperones]; Pfam:PF00226:DnaJ domain; PRINTS:PR00625:DnaJ domain; ProSiteProfiles:PS50076:DnaJ domain; SMART:SM00271:DnaJ domain; SUPERFAMILY:SSF46565:DnaJ domain.
  
 
 0.650
AHY46478.1
TIGRFAM:TIGR00229:PAS domain; COG:COG4585: Signal transduction histidine kinase [Signal transduction mechanisms]; Pfam:PF08448:PAS fold-4; ProSiteProfiles:PS50113:PAS-associated, C-terminal; SMART:SM00065:GAF domain; SUPERFAMILY:SSF55785:PAS domain; sensory_box.
   
 
 0.643
AHY46230.1
TIGRFAM:TIGR00229:PAS domain; COG:COG4585: Signal transduction histidine kinase [Signal transduction mechanisms]; Pfam:PF08447:PAS fold-3; ProSiteProfiles:PS50112:PAS domain; SMART:SM00065:GAF domain; SUPERFAMILY:SSF55785:PAS domain; sensory_box.
   
 
 0.634
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (10%) [HD]
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