STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46007.1TIGRFAM:TIGR01327:D-3-phosphoglycerate dehydrogenase; COG:COG0111: Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Pfam:PF02826:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; ProSitePatterns:PS00670:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; SUPERFAMILY:SSF51735:No Description;KEGG: 00260; KEGG: 00680; UniPathway: UPA00135. (539 aa)    
Predicted Functional Partners:
AHY46511.1
COG:COG0406: Fructose-26-bisphosphatase [Carbohydrate transport and metabolism]; Pfam:PF00300:Histidine phosphatase superfamily, clade-1; Pfam:PF00300:Histidine phosphatase superfamily, clade-1; ProSitePatterns:PS00175:Phosphoglycerate/bisphosphoglycera te mutase, active site; SMART:SM00855:Histidine phosphatase superfamily, clade-1; SUPERFAMILY:SSF53254:No Description.
  
 
 0.905
AHY45580.1
apgM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; TIGRFAM:TIGR00306:Bisphosphoglycerate-independent phosphoglycerate mutase; COG:COG3635: Predicted phosphoglycerate mutase AP superfamily [Carbohydrate transport and metabolism]; Pfam:PF10143:Bisphosphoglycerate-independent phosphoglycerate mutase; PIRSF:PIRSF006392:Bisphosphoglycerate-independent phosphoglycerate mutase; SUPERFAMILY:SSF53649:Alkaline-phosphatase-like, core domain;KEGG: 00010; KEGG: 00680; MetaCyc: PWY-2221; UniPathway: UPA00109.
    
 0.903
AHY46006.1
COG:COG0075: Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Pfam:PF00266:Aminotransferase, class V/Cysteine desulfurase; Pfam:PF00266:Aminotransferase, class V/Cysteine desulfurase; PIRSF:PIRSF000524:Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase; ProSitePatterns:PS00595:Aminotransferase class-V pyridoxal-phosphate binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
  
  
 0.827
AHY46008.1
Pfam:PF14168:YjzC-like protein.
       0.689
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
   
 
 0.673
AHY46009.1
GGDEF: diguanylate cyclase (GGDEF) domain; TIGRFAM:TIGR00254:GGDEF domain; COG:COG2206: HD-GYP domain [Signal transduction mechanisms]; Pfam:PF13487:HD domain; ProSiteProfiles:PS50887:GGDEF domain; SMART:SM00471:HD/PDEase domain; SUPERFAMILY:SSF109604:No Description.
       0.649
AHY45433.1
AAA domain; COG:COG0572: Uridine kinase [Nucleotide transport and metabolism]; Pfam:PF13207:AAA domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
   
  0.597
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.532
rplF
Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
   0.515
AHY45510.1
thrC: threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.503
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.