STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AHY46012.1metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1260 aa)    
Predicted Functional Partners:
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
 
 
0.999
AHY45913.1
COG:COG0685: 510-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Pfam:PF02219:Methylenetetrahydrofolate reductase; Pfam:PF02219:Methylenetetrahydrofolate reductase; SUPERFAMILY:SSF51730:No Description; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.998
AHY47788.1
Cobalamin-independent synthase, Catalytic domain; COG:COG0620: Methionine synthase II (cobalamin-independent) [Amino acid transport and metabolism]; Pfam:PF01717:Methionine synthase, vitamin-B12 independent; SUPERFAMILY:SSF51726:No Description;MetaCyc: PWY-702; UniPathway: UPA00051.
  
 
 0.977
AHY46330.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; TIGRFAM:TIGR01326:O-acetylhomoserine/O-acetylserine sulfhydrylase; COG:COG2873: O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Pfam:PF01053:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PIRSF:PIRSF001434:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; ProSitePatterns:PS00868:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00270; MetaCyc: PWY-5344; OAH_OAS_sulfhy.
  
 
 0.962
AHY47060.1
COG:COG0499: S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Pfam:PF05221:Adenosylhomocysteinase; Pfam:PF05221:Adenosylhomocysteinase; PIRSF:PIRSF001109:Adenosylhomocysteinase; SMART:SM00996:Adenosylhomocysteinase; SUPERFAMILY:SSF52283:No Description.
  
 
 0.962
fhs
COG:COG2759: Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Pfam:PF01268:Formate-tetrahydrofolate ligase, FTHFS; Hamap:MF_01543:Formate-tetrahydrofolate ligase, FTHFS; Pfam:PF01268:Formate-tetrahydrofolate ligase, FTHFS; ProSitePatterns:PS00722:Formate-tetrahydrofolate ligase, FTHFS, conserved site; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.961
metK
metK: methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.961
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.949
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
  
 
 0.948
AHY45915.1
COG:COG0404: Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; Pfam:PF01571:Glycine cleavage T-protein, N-terminal; PIRSF:PIRSF006487:Glycine cleavage system T protein; SUPERFAMILY:SSF103025:No Description; Belongs to the GcvT family.
  
 
 0.940
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (26%) [HD]
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