STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46022.1DnaB: replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (459 aa)    
Predicted Functional Partners:
dnaG
dnaG: DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family.
 0.958
AHY45335.1
COG:COG1484: DNA replication protein [DNA replication recombination and repair]; Pfam:PF01695:IstB-like ATP-binding protein; Pfam:PF01695:IstB-like ATP-binding protein; SMART:SM00382:AAA+ ATPase domain; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase.
  
 
 0.906
dnaA
DnaA: chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 
 
 0.846
AHY46023.1
Pfam:PF14328:Protein of unknown function DUF4385.
       0.773
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
 
  
 0.691
AHY45338.1
TIGRFAM:TIGR00621:Single-strand DNA-binding; COG:COG0629: Single-stranded DNA-binding protein [DNA replication recombination and repair]; Pfam:PF00436:Primosome PriB/single-strand DNA-binding; PIRSF:PIRSF002070:Single-strand DNA-binding; ProSiteProfiles:PS50935:Primosome PriB/single-strand DNA-binding; SUPERFAMILY:SSF50249:Nucleic acid-binding, OB-fold.
 
 
 0.679
rplI
L9: ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.677
rpoA
rpoA: DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
  
 0.667
AHY47829.1
UvrD/REP helicase N-terminal domain; COG:COG0210: Superfamily I DNA and RNA helicases [DNA replication recombination and repair]; Pfam:PF00580:UvrD-like Helicase, ATP-binding domain; ProSiteProfiles:PS51217:DNA helicase, UvrD-like, C-terminal; SUPERFAMILY:SSF52540:P-loop containing nucleoside triphosphate hydrolase; Belongs to the helicase family. UvrD subfamily.
  
 
 0.659
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.639
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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