STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (330 aa)    
Predicted Functional Partners:
glmU
glmU: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
  
 0.987
AHY45341.1
COG:COG0021: Transketolase [Carbohydrate transport and metabolism]; Pfam:PF00456:Transketolase, N-terminal; Pfam:PF00456:Transketolase, N-terminal; ProSitePatterns:PS00802:Transketolase binding site; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
   
 
 0.951
purF
purF: amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.943
AHY47758.1
Dehydrogenase E1 component; COG:COG0022: Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit [Energy production and conversion]; Pfam:PF00676:Dehydrogenase, E1 component; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
  
 0.940
rbsK
Sugar kinases ribokinase family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.929
rpiA
rpiA: ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
  
 
 0.926
deoB
deoB: phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
     
 0.912
AHY47698.1
NUDIX domain; COG:COG1051: ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Pfam:PF00293:NUDIX hydrolase domain; ProSitePatterns:PS00893:NUDIX hydrolase, conserved site; ProSiteProfiles:PS51462:NUDIX hydrolase domain; SUPERFAMILY:SSF55811:NUDIX hydrolase domain-like.
  
 
 0.912
AHY47721.1
NUDIX domain; COG:COG1051: ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Pfam:PF00293:NUDIX hydrolase domain; ProSitePatterns:PS00893:NUDIX hydrolase, conserved site; ProSiteProfiles:PS51462:NUDIX hydrolase domain; SUPERFAMILY:SSF55811:NUDIX hydrolase domain-like.
  
 
 0.912
rplY
Ribosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.867
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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