STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pthPth: peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (204 aa)    
Predicted Functional Partners:
rplY
Ribosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
 
  
 0.860
ychF
TIGR00092: GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
 
  
 0.848
prfB
prfB: peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
 
  
 0.732
prfA
prfA: peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
   
 0.670
guaA
GMP synthase (glutamine-hydrolyzing), C-terminal domain; Catalyzes the synthesis of GMP from XMP.
  
  
 0.665
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
 
 0.651
mfd
Mfd: transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
  
 0.645
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
  
 0.620
pheT
TIGRFAM:TIGR00472:Phenylalanine-tRNA ligase, class IIc, beta subunit, bacterial; COG:COG0072: Phenylalanyl-tRNA synthetase beta subunit [Translation ribosomal structure and biogenesis]; Pfam:PF03483:B3/B4 tRNA-binding domain; Hamap:MF_00283:Phenylalanine-tRNA ligase, class IIc, beta subunit, bacterial; ProSiteProfiles:PS51483:tRNA synthetase, B5-domain; SMART:SM00873:B3/B4 tRNA-binding domain; SUPERFAMILY:SSF56037:Phenylalanyl-tRNA synthetase, B3/B4;KEGG: 00970; pheT_bact.
     
 0.570
AHY47087.1
COG:COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication recombination and repair]; Pfam:PF00476:DNA-directed DNA polymerase, family A, palm domain; PRINTS:PR00868:DNA polymerase A; ProSitePatterns:PS00447:DNA-directed DNA polymerase, family A, conserved site; SMART:SM00475:5'-3' exonuclease, N-terminal; SUPERFAMILY:SSF56672:No Description.
 
   
 0.570
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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