STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46083.1TIGRFAM:TIGR01064:Pyruvate kinase; COG:COG0469: Pyruvate kinase [Carbohydrate transport and metabolism]; Pfam:PF00224:Pyruvate kinase, barrel; PRINTS:PR01050:Pyruvate kinase; ProSitePatterns:PS00110:Pyruvate kinase, active site; SUPERFAMILY:SSF51621:Pyruvate/Phosphoenolpyruvate kinase-like domain;KEGG: 00010; KEGG: 00230; KEGG: 00620; KEGG: 00710; MetaCyc: PWY-2221; Reactome: REACT_474; UniPathway: UPA00109; pyruv_kin. (474 aa)    
Predicted Functional Partners:
eno
Eno: phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.999
pgk
COG:COG0126: 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Pfam:PF00162:Phosphoglycerate kinase; Hamap:MF_00145:Phosphoglycerate kinase; Pfam:PF00162:Phosphoglycerate kinase; PIRSF:PIRSF000724:Phosphoglycerate kinase; PRINTS:PR00477:Phosphoglycerate kinase; ProSitePatterns:PS00111:Phosphoglycerate kinase, conserved site; SUPERFAMILY:SSF53748:Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.999
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
 
 0.997
pfp
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
 
 0.997
AHY46470.1
Hypothetical Protein; Ab initio prediction:Prodigal:2.60.
   
    0.986
AHY46383.1
COG:COG0281: Malic enzyme [Energy production and conversion]; Pfam:PF03949:Malic enzyme, NAD-binding; Pfam:PF03949:Malic enzyme, NAD-binding; PIRSF:PIRSF000106:Malic oxidoreductase; PRINTS:PR00072:Malic oxidoreductase; ProSitePatterns:PS00331:Malic enzyme, conserved site; SMART:SM00919:Malic enzyme, NAD-binding; SUPERFAMILY:SSF51735:No Description.
  
 0.971
AHY47772.1
COG:COG1052: Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Pfam:PF02826:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; Pfam:PF02826:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; ProSitePatterns:PS00670:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; SUPERFAMILY:SSF51735:No Description.
  
 0.968
AHY47470.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.965
AHY45341.1
COG:COG0021: Transketolase [Carbohydrate transport and metabolism]; Pfam:PF00456:Transketolase, N-terminal; Pfam:PF00456:Transketolase, N-terminal; ProSitePatterns:PS00802:Transketolase binding site; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
  
 0.952
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.952
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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