STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46111.1COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase. (378 aa)    
Predicted Functional Partners:
hisB
COG:COG0131: Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism]; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; Hamap:MF_00076:Imidazoleglycerol-phosphate dehydratase; Pfam:PF00475:Imidazoleglycerol-phosphate dehydratase; ProSitePatterns:PS00954:Imidazoleglycerol-phosphate dehydratase, conserved site; SUPERFAMILY:SSF54211:Ribosomal protein S5 domain 2-type fold.
 
 0.999
hisI
TIGRFAM:TIGR03188:Phosphoribosyl-ATP pyrophosphohydrolase; COG:COG0139: Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Pfam:PF01502:Phosphoribosyl-AMP cyclohydrolase domain; Hamap:MF_01020:Phosphoribosyl-ATP pyrophosphohydrolase; SUPERFAMILY:SSF141734:No Description;KEGG: 00340; UniPathway: UPA00031; histidine_hisI; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.997
hisD
hisD: histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.987
cobQ
cobQ: cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.981
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.980
AHY47443.1
COG:COG0287: Prephenate dehydrogenase [Amino acid transport and metabolism]; Pfam:PF02153:Prephenate dehydrogenase; Pfam:PF02153:Prephenate dehydrogenase; ProSiteProfiles:PS51176:Prephenate dehydrogenase; SUPERFAMILY:SSF51735:No Description.
 
 
 0.967
AHY46506.1
COG:COG0077: Prephenate dehydratase [Amino acid transport and metabolism]; Pfam:PF00800:Prephenate dehydratase; Pfam:PF00800:Prephenate dehydratase; PIRSF:PIRSF001500:Bifunctional P-protein, chorismate mutase/prephenate dehydratase; ProSiteProfiles:PS51168:Chorismate mutase; SMART:SM00830:Chorismate mutase; SUPERFAMILY:SSF53850:No Description.
  
 
 0.956
AHY46968.1
COG:COG0436: Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Pfam:PF00155:Aminotransferase, class I/classII; ProSitePatterns:PS00105:Aminotransferases, class-I, pyridoxal-phosphate-binding site; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase.
 
 
0.927
hisC
COG:COG0079: Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Pfam:PF00155:Aminotransferase, class I/classII; Hamap:MF_01023:Histidinol-phosphate aminotransferase family; Pfam:PF00155:Aminotransferase, class I/classII; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
  
 
0.927
cobB
cobB: cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.920
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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