STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rbsKSugar kinases ribokinase family; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (310 aa)    
Predicted Functional Partners:
deoC
deoC: deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
   
 0.982
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.929
AHY45341.1
COG:COG0021: Transketolase [Carbohydrate transport and metabolism]; Pfam:PF00456:Transketolase, N-terminal; Pfam:PF00456:Transketolase, N-terminal; ProSitePatterns:PS00802:Transketolase binding site; SMART:SM00861:Transketolase-like, pyrimidine-binding domain; SUPERFAMILY:SSF52518:No Description.
  
 0.925
AHY46127.1
COG:COG1609: Transcriptional regulators [Transcription]; Pfam:PF13377:Periplasmic binding protein-like domain; Pfam:PF13377:Periplasmic binding protein-like domain; ProSiteProfiles:PS50932:Transcription regulator HTH, LacI; SMART:SM00354:Transcription regulator HTH, LacI; SUPERFAMILY:SSF53822:No Description.
  
 0.921
rpiA
rpiA: ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.916
deoB
deoB: phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
   
 
 0.903
pdxS
TIGR00343: pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
     
 0.817
pdxT
Pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
     
 0.817
AHY47743.1
COG:COG1172: Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components [Carbohydrate transport and metabolism]; Pfam:PF02653:ABC transporter, permease; Pfam:PF02653:ABC transporter, permease.
 
  
 0.778
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM:TIGR00007:Phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA; COG:COG0106: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Pfam:PF00977:Histidine biosynthesis; Hamap:MF_01014:Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; SUPERFAMILY:SSF51366:Ribulose-phosphate binding barrel;KEGG: 00340; UniPathway: UPA00031.
  
  
 0.629
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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