STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
argHTIGRFAM:TIGR00838:Argininosuccinate lyase; COG:COG0165: Argininosuccinate lyase [Amino acid transport and metabolism]; Pfam:PF00206:Fumarate lyase, N-terminal; Hamap:MF_00006:Argininosuccinate lyase; PRINTS:PR00145:Delta crystallin; ProSitePatterns:PS00163:Fumarate lyase, conserved site; SUPERFAMILY:SSF48557:L-Aspartase-like;KEGG: 00250; KEGG: 00330; MetaCyc: PWY-4983; MetaCyc: PWY-5; UniPathway: UPA00068. (468 aa)    
Predicted Functional Partners:
argG
TIGRFAM:TIGR00032:Argininosuccinate synthase; COG:COG0137: Argininosuccinate synthase [Amino acid transport and metabolism]; Pfam:PF00764:Argininosuccinate synthase; Hamap:MF_00005:Argininosuccinate synthase, type 1 subfamily; ProSitePatterns:PS00565:Argininosuccinate synthase, conserved site; SUPERFAMILY:SSF69864:No Description;KEGG: 00250; KEGG: 00330; MetaCyc: PWY-4983; MetaCyc: PWY-5; UniPathway: UPA00068; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
 0.999
AHY47584.1
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
  
 0.980
argR
Arginine repressor; Regulates arginine biosynthesis genes.
  
  
 0.968
argC
argC: N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.957
argB
argB: acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.949
argD
TIGRFAM:TIGR00707:Transaminase, Acetylornithine/Succinylornithine family; COG:COG4992: Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Pfam:PF00202:Aminotransferase class-III; Hamap:MF_01107:Transaminase, Acetylornithine/Succinylornithine family; PIRSF:PIRSF000521:No Description; ProSitePatterns:PS00600:Aminotransferase class-III; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.913
AHY46189.1
TIGRFAM:TIGR00928:Adenylosuccinate lyase; COG:COG0015: Adenylosuccinate lyase [Nucleotide transport and metabolism]; Pfam:PF00206:Fumarate lyase, N-terminal; PRINTS:PR00149:Fumarate lyase; ProSitePatterns:PS00163:Fumarate lyase, conserved site; SMART:SM00998:Adenylosuccinate lyase C-terminal; SUPERFAMILY:SSF48557:L-Aspartase-like;KEGG: 00230; KEGG: 00250; MetaCyc: PWY-6123; MetaCyc: PWY-841; UniPathway: UPA00074; UniPathway: UPA00075; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
0.912
argJ
ArgJ: glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.888
AHY47450.1
COG:COG1051: ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Pfam:PF00293:NUDIX hydrolase domain; Pfam:PF00293:NUDIX hydrolase domain; PRINTS:PR00502:NUDIX hydrolase; ProSitePatterns:PS00893:NUDIX hydrolase, conserved site; ProSiteProfiles:PS51462:NUDIX hydrolase domain; SUPERFAMILY:SSF55811:NUDIX hydrolase domain-like; Belongs to the Nudix hydrolase family.
      0.870
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.847
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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