STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
purCTIGRFAM:TIGR00081:SAICAR synthetase; COG:COG0152: Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase [Nucleotide transport and metabolism]; Pfam:PF01259:SAICAR synthetase; Hamap:MF_00137:SAICAR synthetase; ProSitePatterns:PS01057:SAICAR synthetase, conserved site; SUPERFAMILY:SSF56104:No Description;KEGG: 00230; MetaCyc: PWY-6123; UniPathway: UPA00074. (234 aa)    
Predicted Functional Partners:
AHY46189.1
TIGRFAM:TIGR00928:Adenylosuccinate lyase; COG:COG0015: Adenylosuccinate lyase [Nucleotide transport and metabolism]; Pfam:PF00206:Fumarate lyase, N-terminal; PRINTS:PR00149:Fumarate lyase; ProSitePatterns:PS00163:Fumarate lyase, conserved site; SMART:SM00998:Adenylosuccinate lyase C-terminal; SUPERFAMILY:SSF48557:L-Aspartase-like;KEGG: 00230; KEGG: 00250; MetaCyc: PWY-6123; MetaCyc: PWY-841; UniPathway: UPA00074; UniPathway: UPA00075; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.998
purM
TIGRFAM:TIGR00878:Phosphoribosylformylglycinamidine cyclo-ligase; COG:COG0150: Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Pfam:PF02769:AIR synthase-related protein, C-terminal domain; SUPERFAMILY:SSF56042:AIR synthase-related protein, C-terminal domain;KEGG: 00230; MetaCyc: PWY-6121; UniPathway: UPA00074.
 
  
 0.986
purF
purF: amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.985
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
 
  
 0.983
purH
purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM:TIGR00355:AICARFT/IMPCHase bienzyme; COG:COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Pfam:PF01808:AICARFT/IMPCHase bienzyme; Hamap:MF_00139:AICARFT/IMPCHase bienzyme; PIRSF:PIRSF000414:AICARFT/IMPCHase bienzyme; SMART:SM00798:AICARFT/IMPCHase bienzyme; SUPERFAMILY:SSF53927:Cytidine deaminase-like;KEGG: 00230; KEGG: 00670; MetaCyc: PWY-6123; UniPathway: UPA00074; UniPathway: UPA00074.
 
 
 0.983
purD
purD: phosphoribosylamine--glycine ligase; TIGRFAM:TIGR00877:Phosphoribosylglycinamide synthetase; COG:COG0151: Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Pfam:PF01071:Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Hamap:MF_00138:Phosphoribosylglycinamide synthetase; ProSitePatterns:PS00184:Phosphoribosylglycinamide synthetase, conserved site; ProSiteProfiles:PS50975:ATP-grasp fold; SUPERFAMILY:SSF56059:No Description;KEGG: 00230; MetaCyc: PWY-6121; UniPathway: UPA00074; Belongs to the GARS family.
 
 
 0.981
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
 
 0.981
purS
TIGR00302: phosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...]
  
  
 0.979
purN
PurN: phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.976
purA
purA: adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.898
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
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