STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHY46330.1O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; TIGRFAM:TIGR01326:O-acetylhomoserine/O-acetylserine sulfhydrylase; COG:COG2873: O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Pfam:PF01053:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PIRSF:PIRSF001434:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; ProSitePatterns:PS00868:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SUPERFAMILY:SSF53383:Pyridoxal phosphate-dependent transferase;KEGG: 00270; MetaCyc: PWY-5344; OAH_OAS_sulfhy. (435 aa)    
Predicted Functional Partners:
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 0.996
AHY46332.1
COG:COG0460: Homoserine dehydrogenase [Amino acid transport and metabolism]; Pfam:PF00742:Homoserine dehydrogenase, catalytic; Pfam:PF00742:Homoserine dehydrogenase, catalytic; PIRSF:PIRSF036497:Homoserine dehydrogenase, short; SUPERFAMILY:SSF55347:No Description.
 
 0.970
AHY47849.1
COG:COG2021: Homoserine acetyltransferase [Amino acid transport and metabolism]; Pfam:PF12697:Alpha/beta hydrolase family; Pfam:PF12697:Alpha/beta hydrolase family; PIRSF:PIRSF000443:Homoserine acetyltransferase; SUPERFAMILY:SSF53474:No Description; Belongs to the AB hydrolase superfamily. MetX family.
 
 
 0.968
AHY46012.1
metH: methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.962
AHY46013.1
Homocysteine S-methyltransferase; COG:COG0646: Methionine synthase I (cobalamin-dependent) methyltransferase domain [Amino acid transport and metabolism]; Pfam:PF02574:Homocysteine S-methyltransferase; ProSiteProfiles:PS50970:Homocysteine S-methyltransferase; SUPERFAMILY:SSF82282:Homocysteine S-methyltransferase.
 
 
 0.955
AHY47788.1
Cobalamin-independent synthase, Catalytic domain; COG:COG0620: Methionine synthase II (cobalamin-independent) [Amino acid transport and metabolism]; Pfam:PF01717:Methionine synthase, vitamin-B12 independent; SUPERFAMILY:SSF51726:No Description;MetaCyc: PWY-702; UniPathway: UPA00051.
  
 
 0.938
AHY46897.1
COG:COG1832: Predicted CoA-binding protein [General function prediction only]; Pfam:PF13380:CoA-binding; Pfam:PF13380:CoA-binding; SMART:SM00881:CoA-binding; SUPERFAMILY:SSF51735:No Description.
      0.919
AHY47060.1
COG:COG0499: S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Pfam:PF05221:Adenosylhomocysteinase; Pfam:PF05221:Adenosylhomocysteinase; PIRSF:PIRSF001109:Adenosylhomocysteinase; SMART:SM00996:Adenosylhomocysteinase; SUPERFAMILY:SSF52283:No Description.
     
 0.917
AHY46105.1
4Fe-4S dicluster domain; COG:COG4231: Indolepyruvate ferredoxin oxidoreductase alpha and beta subunits [Energy production and conversion]; Pfam:PF13187:4Fe-4S ferredoxin-type, iron-sulpur binding domain; ProSitePatterns:PS00198:4Fe-4S ferredoxin, iron-sulphur binding, conserved site; ProSiteProfiles:PS51379:4Fe-4S ferredoxin-type, iron-sulpur binding domain; SUPERFAMILY:SSF54862:No Description.
     
  0.900
AHY48030.1
COG:COG0031: Cysteine synthase [Amino acid transport and metabolism]; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; Pfam:PF00291:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily; ProSitePatterns:PS00901:Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site; SUPERFAMILY:SSF53686:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily.
 
 0.860
Your Current Organism:
Rubrobacter radiotolerans
NCBI taxonomy Id: 42256
Other names: ATCC 51242, Arthrobacter radiotolerans, CIP 106991, DSM 46359, DSM 5868, IAM 12072, IFO 14777, JCM 2153, NBRC 14777, R. radiotolerans, strain P-1
Server load: low (20%) [HD]
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